Atorvastatin Inhibits High-Fat Diet-Induced Lipid Metabolism Disorders in Rats by Inhibiting Bacteroides Reduction and Improving Metabolism

Li, Huimin; Wang, Shue; Wang, Shuai; Yu, Hai; Yu, Wenhao; Ma, Xiaomin; He, Xiaodong

doi:10.2147/dddt.s379335

Cited by 4 publications

(5 citation statements)

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“…Patients with mental disorders often have a variety of sleep problems, such as sleep interruptions and a reduced duration of sleep ( Baglioni et al, 2016 ). Both Dialister related to carbohydrate metabolism ( Gonçalves et al, 2016 ) and Bacteroides related to fat metabolism ( Li et al, 2022 ) were increased in the intestinal tract of adolescents who slept longer, which might be the reason for the different distribution of intestinal microbiota in adolescents with different sleep duration. Given that adolescents are in a critical period of growth and development, a balanced diet could not only help in maintaining a stable intestinal microbiota but also promote a healthy psychological state and improve sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Effects of urbanization and lifestyle habits on the intestinal microbiota of adolescents in eastern China

Zhao

Xie

et al. 2023

Front. Microbiol.

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IntroductionOwing to urbanization, living habits have changed widely, leading to alterations in the intestinal microbiota of urban residents. However, there are few studies on the characteristics of intestinal microbiota of adolescents living in different urbanized areas in China.MethodsA total of 302 fecal samples collected from adolescent students in eastern China were examined. 16S rRNA high-throughput sequencing was used to identify the fecal microbiota. These data were combined with questionnaire survey results to investigate the effect of urbanization on the intestinal microbiota of adolescents in eastern China. Moreover, the role of lifestyle habits in this relationship was also evaluated.ResultsThe results revealed significant differences in the structure of the intestinal microbiota among adolescents living in regions with different levels of urbanization. Adolescents living in urban regions had a significantly higher proportion of Bacteroides (p < 0.001, FDR = 0.004), whereas those living in towns and rural regions had higher proportions of Bifidobacterium (p < 0.001, FDR < 0.001) and Prevotella (p < 0.05, FDR = 0.019). The diversity of the intestinal microbiota was higher in urban residents than in adolescents living in towns and rural regions (p < 0.05). In addition, the differences in intestinal microbiota across individuals living in cities, towns, and rural regions were related to dietary preferences, flavor preferences, and sleep and exercise durations. Adolescents who ate more meat had more Dorea (LDA = 3.622, p = 0.04), while the abundance of Escherichia–Shigella is higher among adolescents who ate more condiments (LDA = 4.285, p = 0.02). The abundance of Dialister was significantly increased in adolescents with longer sleep durations (LDA = 4.066, p = 0.03). Adolescents who exercised for a long duration had more Faecalibacterium than those who exercised for a shorter duration (LDA = 4.303, p = 0.04).DiscussionOur research has preliminarily demonstrated that there were differences in the composition of Gut microbiome in stool samples of adolescents living in different urbanized areas, and provide a scientific basis for the maintenance of a healthy intentional microbota in adolescences.

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Section: Discussionmentioning

confidence: 99%

Effects of urbanization and lifestyle habits on the intestinal microbiota of adolescents in eastern China

Zhao

Xie

et al. 2023

Front. Microbiol.

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“…In recent years, various effective drugs, such as glucose-lowering drugs, antioxidants, lipid-lowering agents, and natural bile acid treatments, have been used to treat NAFLD ( Mantovani and Dalbeni, 2021 ). Interestingly, gut microbiota analysis has shown an increase in Bacteroides abundance after treatment with Raw Bowl Tea polyphenols, atorvastatin, Ganoderma meroterpene derivative, and the prebiotic inulin for NAFLD ( Liu et al, 2019 ; Qiao et al, 2020 ; Aoki et al, 2021 ; Li H. et al, 2022 ). For instance, atorvastatin was found to reduce lipid levels, improve HFD-induced hepatic steatosis, and increase Bacteroides abundance ( Li H. et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, gut microbiota analysis has shown an increase in Bacteroides abundance after treatment with Raw Bowl Tea polyphenols, atorvastatin, Ganoderma meroterpene derivative, and the prebiotic inulin for NAFLD ( Liu et al, 2019 ; Qiao et al, 2020 ; Aoki et al, 2021 ; Li H. et al, 2022 ). For instance, atorvastatin was found to reduce lipid levels, improve HFD-induced hepatic steatosis, and increase Bacteroides abundance ( Li H. et al, 2022 ). In fa/fa rats, the oral administration of Ganoderma meroterpene derivative was shown to reduce de novo lipogenesis, reverse non-alcoholic hepatic steatosis, and enhance Bacteroides abundance ( Qiao et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…Bacteroides have been found to significantly modulate lipid metabolism in animal models ( Lee et al, 2021 ; López-Almela et al, 2021 ; Li H. et al, 2022 ; Xu et al, 2023 ). These studies indicate that Bacteroides ultimately reduce the accumulation of fat in the liver via inhibiting SREBP-1 and ChREBP expression, as well as related adipogenic genes, and by promoting FAO-related pathways.…”

Section: Introductionmentioning

confidence: 99%

“…In vivo evidence for Bacteroides Strain in the treatment of NAFLD -Almela et al, 2021;Li H. et al, 2022;Xu et al, 2023)…”

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Bacteroides and NAFLD: pathophysiology and therapy

Zhang,

Zhou,

et al. 2024

Front. Microbiol.

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Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition observed globally, with the potential to progress to non-alcoholic steatohepatitis (NASH), cirrhosis, and even hepatocellular carcinoma. Currently, the US Food and Drug Administration (FDA) has not approved any drugs for the treatment of NAFLD. NAFLD is characterized by histopathological abnormalities in the liver, such as lipid accumulation, steatosis, hepatic balloon degeneration, and inflammation. Dysbiosis of the gut microbiota and its metabolites significantly contribute to the initiation and advancement of NAFLD. Bacteroides, a potential probiotic, has shown strong potential in preventing the onset and progression of NAFLD. However, the precise mechanism by which Bacteroides treats NAFLD remains uncertain. In this review, we explore the current understanding of the role of Bacteroides and its metabolites in the treatment of NAFLD, focusing on their ability to reduce liver inflammation, mitigate hepatic steatosis, and enhance intestinal barrier function. Additionally, we summarize how Bacteroides alleviates pathological changes by restoring the metabolism, improving insulin resistance, regulating cytokines, and promoting tight-junctions. A deeper comprehension of the mechanisms through which Bacteroides is involved in the pathogenesis of NAFLD should aid the development of innovative drugs targeting NAFLD.

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The Influence of Atorvastatin Treatment on Homocysteine Metabolism and Oxidative Stress in an Experimental Model of Diabetic Rats

Clim,

Maranduca,

Filip

et al. 2024

Life

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Objective: In our experimental study, we evaluated the influence of treatment with atorvastatin on the antioxidant activity of intracellular and extracellular systems factors, homocysteine levels (Hcy), and lipid profiles in obese and diabetic rats. Method: Twenty-one male Wistar rats, aged 6 months, 450–550 g, were allocated into three groups. From the beginning of the study, the first group (G-I, control) received only standard food, while the second and third groups (G II—obese, G III—diabetic) were administered a high-fat diet (HFD) with 2% cholesterol. After 2 weeks of accommodation, the specimens in G-III were injected intraperitoneal (i.p.) streptozotocin (35 mg of body weight, pH 4.5), intervention followed by the onset of type 2 diabetes mellitus. Following confirmation of diabetes onset, the specimens in G III were administered concomitantly with the HFD a daily gavage of atorvastatin 20 mg of body weight/day for 20 days. We measured, at the beginning and the end of the study, the Hcy levels, lipid profile, vitamin B12, B6, folic acid, and various parameters of oxidative stress (OS)—total antioxidant status (TAS), glutathione peroxidase (GPX) and superoxide dismutase (SOD). Results: After treatment with atorvastatin, the lipid profile in G III significantly improved compared to the other two groups, but enzymatic markers of oxidative stress did not closely parallel this trend. However, after the treatment of statin, we observed an important reduction in Hcy values. Conclusion: Our results demonstrate that treatment with atorvastatin can be used not only for its lipid-lowering properties and antioxidant effects but also to reduce Hcy concentration in this experimental model of diabetic rats. Moreover, atorvastatin therapy improves lipid profiles, reduces inflammation, suppresses oxidation, and decreases Hcy levels, potentially preventing major adverse cardiovascular events.

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Atorvastatin Inhibits High-Fat Diet-Induced Lipid Metabolism Disorders in Rats by Inhibiting Bacteroides Reduction and Improving Metabolism

Cited by 4 publications

References 51 publications

Effects of urbanization and lifestyle habits on the intestinal microbiota of adolescents in eastern China

Effects of urbanization and lifestyle habits on the intestinal microbiota of adolescents in eastern China

Bacteroides and NAFLD: pathophysiology and therapy

The Influence of Atorvastatin Treatment on Homocysteine Metabolism and Oxidative Stress in an Experimental Model of Diabetic Rats

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