2010
DOI: 10.1016/j.urology.2009.05.030
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Atorvastatin Protects Renal Function in the Rat With Acute Unilateral Ureteral Obstruction

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Cited by 9 publications
(4 citation statements)
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“…As the ATV treatment significantly decreased creatinine serum levels, it could be assumed that this drug does not produce renal disturbances. In fact, several studies have reported that statin therapy does not induce tubular dysfunction (18) or alter glomerular filtration, even in higher doses (19) and that may afford protection of renal function in acute unilateral ureteral obstruction (20).…”
Section: Discussionmentioning
confidence: 99%
“…As the ATV treatment significantly decreased creatinine serum levels, it could be assumed that this drug does not produce renal disturbances. In fact, several studies have reported that statin therapy does not induce tubular dysfunction (18) or alter glomerular filtration, even in higher doses (19) and that may afford protection of renal function in acute unilateral ureteral obstruction (20).…”
Section: Discussionmentioning
confidence: 99%
“…Statins may also limit reactive oxygen species production, interfere with the inflammatory cascade, and protect against complement‐mediated injury . In ischemia‐reperfusion models, statins have been shown to improve both glomerular and tubular function …”
Section: Discussionmentioning
confidence: 99%
“…24,25 In ischemia-reperfusion models, statins have been shown to improve both glomerular and tubular function. 26,27 The current analysis offers relevant advantages, when compared with earlier analyses conducted within large databases. Although observational data sets may be able to achieve a high degree of precision based on their very large sample size, such analyses are unable to exclude the possibility that their findings may be explained by residual confounding.…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, statins remain beneficial in neonatal rodent UUO where an improvement in tubular dilatation and glomerular number and size are also seen [ 67 , 79 , 85 ]. Functionally, in UUO models, statins improve GFR and microalbuminuria [ 156 ] and increase urinary concentrating ability via boosting AQP2 expression [ 157 ].…”
Section: Potential Therapeutic Molecular Targets In Pujomentioning
confidence: 99%