Atorvastatin Reduces Plasma Inflammatory and Oxidant Biomarkers in Patients With Risk of Atherosclerotic Cardiovascular Disease

Abstract

Key markers of oxidative stress/inflammation such as CRP, ET-1, total nitrite, and MPO are associated with an increased risk of ASCVD. Moderate- and high-intensity atorvastatin use reduces plasma oxidative stress and inflammation regardless of ASCVD risk and independent of its lipid-lowering effect.

A Systematic Review and Meta-Analysis of the Effect of Statins on Glutathione Peroxidase, Superoxide Dismutase, and Catalase

“…A total of 1970 were excluded (duplicates or irrelevant). After reviewing the remaining 18 articles, 3 were further excluded, leaving 15, reporting 17 treatment arms in 773 patients (mean age of 53 years, 54% males), for final analysis ( Figure 1 and Table 1 ) [ 27 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ].…”

The role of fish oil in attenuating cardiac oxidative stress, inflammation and fibrosis in rat model of thyrotoxicosis

“…Endothelin-1 (ET-1) is a potent vasoconstrictor and inflammatory factor that is produced by endothelial cells, fibroblasts and cardiac myocytes [36]. We have shown that patients with history of recent MI have increased plasma levels of ET-1 and increased risk of atherosclerotic cardiovascular events indicating a link to endothelial dysfunction [37, 38]. Furthermore, patients with hyperthyroidism have increased levels of plasma ET1 and this increase is associated with increased risk of atrial fibrillation [39, 40].…”

Effect of statin therapy on plasma C-type Natriuretic Peptides and Endothelin-1 in males with and without symptomatic coronary artery disease

“…However, none of these studies examined plasma levels within days of commencing therapy. The significant decline at day 7 noted in Group 3 of the current study, and associated fall in hsCRP presumably relates to reduced inflammation post ictus 32,33 . Values after 7 days remained unchanged despite a further fall in hsCRP suggesting that only severe inflammation affects ET-1 expression and circulating levels in this age group.…”