Atorvastatin reduces plasminogen activator inhibitor-1 expression in adipose tissue of atherosclerotic rabbits

Effect of Atorvastatin Versus Rosuvastatin on Levels of Serum Lipids, Inflammatory Markers and Adiponectin in Patients with Hypercholesterolemia

“…Atorvastatin has direct effects on the differentiation, apoptosis and endocrine function of adipocytes and can inhibit insulin-induced glucose uptake in differentiated white adipocytes as well as elevate serum adiponectin levels in CAD patients (5,44). It can even decrease PAI-1, suggesting that it may have an antithrombotic effect (45). Treatment with rosiglitazone, then atorvastatin not only improved lipid profiles but also further increased adiponectin level by 124% in patients with type 2 diabetes mellitus (46).…”

Up-regulating PPAR-γ expression and NO concentration, and down-regulating PAI-1 concentration in a rabbit atherosclerotic model: The possible antiatherogenic and antithrombotic effects of atorvastatin

“…The dose treating was kept from two weeks to 3 months. The levels of the plasma total cholesterol (TC) and the low-density lipoprotein cholesterol (LDL-C) were significantly lower than that of the cholesterol fed group [14][15][16]. The feedstuff with the drug was administered daily by adding it to a small chow dispenser that made chow pellets available and ensured the ingestion of the entire dose.…”

“…Statins with pleiotropic effects [12,13] could not only enhance the activity of endothelial NO synthase (eNOS), but also reduce plasma PAI-1 concentration in adipose tissues [14,15]. However, whether there is a relationship between atorvastatin's effects on PAI-1/NO and activation of PPAR-γ remains poorly known.…”

Effects of Lipid-Altering Therapies on Ventricular Arrhythmias and Sudden Cardiac Death

“…23,24 Statins may also favorably affect thrombus formation, erythrocyte deformability, and levels of plasminogen activator inhibitor-1 and fibrinogen, as well. 25 They inhibit neutrophil and macrophage infiltration, 26 which have been proposed as mechanisms of ischemia-induced arrhythmias. Statins also improve autonomic function by reducing sympathetic activation.…”