ATP-adenosine axis regulation combined with microneedle assisted photoimmunotherapy to boost the immunotherapy efficiency

Coordination catalysis of metals and polydopamine enables controlled release of CO from MnCO by enhancing oxidative stress and the thermal effect

“…22,23 In addition, PTT can trigger immunogenic cell death (ICD) in tumor cells. [24][25][26] The dying tumor cells would release damage-associated molecular patterns (DAMPs), e.g., adenosine triphosphate (ATP), calreticulin (CRT) and high mobility group box 1 (HMGB1), which could subsequently trigger the chain of immune responses. 27 Polydopamine (PDA) possesses favorable biocompatibility, high thermal stability and photothermal conversion efficiency, 28 which make it an excellent choice for the fabrication of photothermal agents.…”

“…22,23 In addition, PTT can trigger immunogenic cell death (ICD) in tumor cells. 24–26 The dying tumor cells would release damage-associated molecular patterns (DAMPs), e.g. , adenosine triphosphate (ATP), calreticulin (CRT) and high mobility group box 1 (HMGB1), which could subsequently trigger the chain of immune responses.…”