1992
DOI: 10.1007/bf02783897
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ATP-dependent strontium uptake by basolateral membrane vesicles from rat renal cortex in the absence or presence of calcium

Abstract: ATP-dependent Sr2+ transport was examined in vitro using basolateral membrane (BLM) vesicles isolated from rat renal cortex to clarify the discrimination mechanisms between strontium (Sr) and calcium (Ca) in renal tubules during reabsorption. ATP-dependent Sr2+ uptake and Ca2+ uptake were observed in renal BLM vesicles and were inhibited by vanadate. Hill plots indicate similar kinetic behavior for Ca2+ and Sr2+ uptake. The apparent Km and Vmax of ATP-dependent Sr2+ uptake were both higher than those for Ca2+ … Show more

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(1 citation statement)
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“…Strontium belongs to the same group with Ca and Mg, forming divalent cations, and have varying degrees of protein binding in biological fluids like serum or plasma (Skoryna 1981;Sugihira, Aoki, and Suzuki 1992;Yu and Inesi 1995). Previous studies have shown that strontium is able to interact with ligands that normally bind calcium including hydroxyapatite, the main component of mineralized bone, and may interact with various calcium-binding and calcium-transport proteins (Harrison et al 1995;Schoenberg 1963;Lloyd 1968;Twardock et al 1971;Kshirsagar 1977;Alda and Escanero 1985;McCormack and Osbaldeston 1990).…”
Section: Introductionmentioning
confidence: 96%
“…Strontium belongs to the same group with Ca and Mg, forming divalent cations, and have varying degrees of protein binding in biological fluids like serum or plasma (Skoryna 1981;Sugihira, Aoki, and Suzuki 1992;Yu and Inesi 1995). Previous studies have shown that strontium is able to interact with ligands that normally bind calcium including hydroxyapatite, the main component of mineralized bone, and may interact with various calcium-binding and calcium-transport proteins (Harrison et al 1995;Schoenberg 1963;Lloyd 1968;Twardock et al 1971;Kshirsagar 1977;Alda and Escanero 1985;McCormack and Osbaldeston 1990).…”
Section: Introductionmentioning
confidence: 96%