2022
DOI: 10.3389/fgene.2022.958290
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ATP6AP1 is a potential prognostic biomarker and is associated with iron metabolism in breast cancer

Abstract: Cancer occurrence and progression may be facilitated by aberrant expression of ATPase H+ transporting accessory protein 1 (ATP6AP1). However, the clinical relevance of ATP6AP1 in breast cancer remains unclear. In this study, we investigated the association between ATP6AP1 and breast cancer. Data collected from patients with breast cancer from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were used in this study. To determine the relationship between ATP6AP1 and breast cancer survival rat… Show more

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Cited by 5 publications
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“… 44 The ATP6AP1 protein is altered in numerous tumors, including head and neck carcinoma, lung cancer, and leukemia. 45 …”
Section: Discussionmentioning
confidence: 99%
“… 44 The ATP6AP1 protein is altered in numerous tumors, including head and neck carcinoma, lung cancer, and leukemia. 45 …”
Section: Discussionmentioning
confidence: 99%
“…Jansen EJ depicted that ATP6AP1 deficiency was capable of leading to immunodeficiency with hepatopathy [ 16 ]. Both Tian Y. et al and Wang J. et al reported that ATP6AP1 was related to the progress and prognosis of breast cancer and might become a biomarker of breast cancer prognosis [ 59 , 60 ]. HSP90AB1 (heat shock protein 90 alpha family class B member 1) encodes a member of the heat shock protein 90 family, involved in signal transduction, protein folding and degradation and morphological evolution.…”
Section: Discussionmentioning
confidence: 99%