ATPase activity of erythrocyte membrane in patients with trisomy 21 (Down's syndrome)

Abstract

ATPase activity of erythrocyte membranes was determined in 25 cases of Down's syndrome verified by cytological and psychological examinations. The age range of the patients was 8-25 years; 16 males and 9 females. Thirty healthy male volunteers were selected as the control group. There was a marked reduction of total ATPase, Na', K+-ATPase, Mg' +-ATPase activities and rate of ouabain inhibition in the patients with Down's syndrome. The authors suggest that there might exist transport defects in the red cell membranes in such patients.