ATR-FTIR characterization of generic brand-named and counterfeit sildenafil- and tadalafil-based tablets found on the Brazilian market

Neto, José Coelho; Lisboa, Fernanda L.C.

doi:10.1016/j.scijus.2017.04.009

Cited by 28 publications

(7 citation statements)

References 20 publications

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“…The A-IBP coating spectrum exhibits a broad OH stretching vibration band that is likely due to excipients in the formulation, including hydroxypropyl methylcellulose 24–26 and sodium croscarmellose. 27–29 The shoulder at 3560 cm −1 may indicate the presence of polysorbate 80. 30–32 The E-IBP coating spectrum contains a sharp band near 1700 cm −1 characteristic of the CO stretching vibration of ibuprofen that is not present in the A-IBP spectrum.…”

Section: Resultsmentioning

confidence: 99%

Discrimination of commercial ibuprofen tablets by using a button sample holder and mid-infrared spectroscopy

Singh

White

2022

Anal. Methods

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Section: Resultsmentioning

confidence: 99%

Discrimination of commercial ibuprofen tablets by using a button sample holder and mid-infrared spectroscopy

Singh

White

2022

Anal. Methods

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“…In 2017, 13 confiscated tablets falsely labeled as "Viagra", circulating in the Brazilian market, were examined by infrared spectroscopy. 10 tablets demonstrated reduced dosages of sildenafil, and 8 tablets contained starch and 6 tablets contained calcium sulfate as undesired substances (Neto, Lisboa, 2017).…”

Section: Introductionmentioning

confidence: 99%

Counterfeit medicines: relevance, consequences and strategies to combat the global crisis

Lima

Yonamine

2023

Braz. J. Pharm. Sci.

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Counterfeiting of medicines, also known as "falsification" or "adulteration", is the process in which the identity, origin, or history of genuine medicines are intentionally modified. Currently, counterfeit medicines are a global crisis that affects and is mostly caused by developing countries in Asia, Africa and Latin America. These countries lack strict law enforcement against this practice and have low-income populations with medicinal needs. Lately, the crisis has escalated, impacting developed countries as well, e.g., the US and the EU, mainly via the Internet. Despite this extension, some current laws aim to control and minimize the crisis' magnitude. Falsification of medicines maintains an illegitimate supply chain that is connected to the legitimate one, both of which are extremely complex, making such falsification difficult to control. Furthermore, political and economic causes are related to the crisis' hasty growth, causing serious consequences for individuals and public health, as well as for the economy of different countries. Recently, organizations, technologies and initiatives have been created to overcome the situation. Nevertheless, the development of more effective measures that could aggregate all the existing strategies into a large functioning network could help prevent the acquisition of counterfeit medicines and create awareness among the general population.

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“…ATR-FTIR was used to determine the polymorphic content of bulk pharmaceutical materials and powder mixtures, and adulteration [ 14 , 15 ]. Several studies have adopted the techniques mentioned above to analyze spectroscopy data in forensic cases, including counterfeit medicines [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Proof-of-Concept of Detection of Counterfeit Medicine through Polymeric Materials Analysis of Plastics Packaging

2021

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The detection of counterfeit pharmaceuticals is always a major challenge, but the early detection of counterfeit medicine in a country will reduce the fatal risk among consumers. Technically, fast laboratory testing is vital to develop an effective surveillance and monitoring system of counterfeit medicines. This study proposed the combination of Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Differential Scanning Calorimetry (DSC) for the quick detection of counterfeit medicines, through the polymer analysis of blister packaging materials. A sample set containing three sets of original and counterfeit medicine was analyzed using ATR-FTIR and DSC, while the spectra from ATR-FTIR were employed as a fingerprint for the polymer characterization. Intending to analyze the polymeric material of each sample, DSC was set at a heating rate of 10 °C min−l and within a temperature range of 0–400 °C, with nitrogen as a purge gas at a flow rate of 20 mL min−1. The ATR-FTIR spectra revealed the chemical characteristics of the plastic packaging of fake and original medicines. Further analysis of the counterfeit medicine’s packaging with DSC exhibited a distinct difference from the original due to the composition of polymers in the packaging material used. Overall, this study confirmed that the rapid analysis of polymeric materials through ATR-FTIR and comparing DSC thermograms of the plastic in their packaging effectively distinguished counterfeit drug products.

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ATR-FTIR characterization of generic brand-named and counterfeit sildenafil- and tadalafil-based tablets found on the Brazilian market

Cited by 28 publications

References 20 publications

Discrimination of commercial ibuprofen tablets by using a button sample holder and mid-infrared spectroscopy

Discrimination of commercial ibuprofen tablets by using a button sample holder and mid-infrared spectroscopy

Counterfeit medicines: relevance, consequences and strategies to combat the global crisis

Proof-of-Concept of Detection of Counterfeit Medicine through Polymeric Materials Analysis of Plastics Packaging

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