Atractylenolide III reduces depressive- and anxiogenic-like behaviors in rat depression models

Zhou, Yu; Huang, Shixian; Wu, Feilong; Zheng, Qiuyao; Zhang, Fu-Shen; Luo, Yunping; Jian, Xiaohong

doi:10.1016/j.neulet.2021.136050

Cited by 39 publications

(20 citation statements)

References 26 publications

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“…Our analysis resulted in 5 DEMs annotated as terpenoids. Among them, atraetylenolide (metab_4566 and metab_2636) is the main active ingredient that has been isolated from Atractylodes rhizomes with anti-inflammatory, gastroprotective and neuroprotective effects ( Zhou et al., 2021 ). Meanwhile, oleanolic acid (metab_10523) and its derivatives possess different pharmacological properties, including anticancer, anti-osteoporosis, antibacterial, antidiabetic, and haemolytic effects ( Ayeleso et al., 2017 ; Gupta, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Utilization of functional agro-waste residues for oyster mushroom production: Nutritions and active ingredients in healthcare

Lyu

et al. 2023

Front. Plant Sci.

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A large amount of agro-industrial residues are produced from the planting, production and processing of traditional Chinese herbs. As a tonic, edible, and economical herb, Codonopsis pilosula root has been extensively developed into medicine and functional food. However, thousands of tons of aerial parts (stems, leaves, flowers and fruits) have been directly discarded after harvest each year. To utilise agro-wastes, Pleurotus ostreatus was cultivated on a basal substrate supplemented with C. pilosula stems and leaves (CSL). Physicochemical analyses revealed that the basal substrate mixed with CSL was more abundant in cellulose, hemicellulose, and most of micronutrients such as K, Ca, Mg, S, Fe, Zn and Mo. After the first flush, the fruit bodies in CSL group exhibited a higher fresh weight, a wider average pileus diameter and a lower moisture level. Nutrition analyses presented a higher protein content and a lower fat content in mushrooms from CSL group compared with control group. Interestingly, 14 amino acids (glutamine, arginine, valine, leucine, and etc.) and 3 micronutrients (Se, Fe and Zn) were increased after CSL addition to the substrate. Based on untargeted metabolomics, a total of 710 metabolites were annotated. Compared with control group, there were 142 and 117 metabolites significantly increased and decreased in the CSL group. Most of them were grouped into classes of amino acids and peptids, fatty acids, carbohydrates, terpenoids, and etc. Moreover, an abundance of phytometabolites from Codonopsis were detected in P. ostreatus from CSL group, including polyacetylenes or polyenes, flavonoids, alkaloids, terpenoids, organic acids, and etc. UPLC-MS/MS results demonstrated that lobetyolin content in the CSL group samples was 0.0058%. In summary, the aerial parts of C. pilosula processed for use in the production of edible mushroom is an emerging strategy to converting agricultural waste into functional foods.

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Section: Resultsmentioning

confidence: 99%

Utilization of functional agro-waste residues for oyster mushroom production: Nutritions and active ingredients in healthcare

Lyu

et al. 2023

Front. Plant Sci.

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“…To determine the effective AT‐III dose for the OA rat model, intra‐articular AT‐III injections of 1 mg/kg and 5 mg/kg were administered before the formal experiments, based on previous reports (Xue et al, 2022; Zhou et al, 2021; Zhu et al, 2021). At the specified time point (Figure 1a), Toluidine Blue staining indicated greater damage in the 1 mg/kg group than in the 5 mg/kg group (Figure 1b).…”

Section: Resultsmentioning

confidence: 99%

“…AT‐III was dissolved in the injection solvent (ddH 2 O: EtOH: PEG400 = 96: 3: 1). Four weeks after the exercise training, the OA animals were intra‐articularly injected with 100 μL of the injection solution containing 0, 1 or 5 mg/kg AT‐III weekly for 6 weeks (Xue et al, 2022; Zhou et al, 2021; Zhu et al, 2021) (Figure 1a). In the NF‐κB pathway rescue experiment, 2 μg/kg of the NF‐κB agonist phorbol 12‐myristate 13‐acetate (PMA) (MCE, USA) was included in the 5 mg/kg AT‐III solution.…”

Section: Methodsmentioning

confidence: 99%

Atractylenolide‐III alleviates osteoarthritis and chondrocyte senescence by targeting NF‐κB signaling

Xu,

Hu,

Cai

et al. 2023

Phytotherapy Research

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Atractylenolide‐III (AT‐III) is well known as its role in antioxidant and anti‐inflammatory. Present study was aimed to figure out its effects on osteoarthritis and potential mechanisms. Rat model, human osteoarthritis cartilage explants as well as rat/human chondrocyte cultures were prepared to test AT‐III's effects on osteoarthritis progression and chondrocyte senescence. Potential targeted molecules of AT‐III were predicted using network pharmacology and molecular docking, assessed by Western blotting and then verified with rescue experiments. AT‐III treatment alleviated osteoarthritis severity (shown by OARSI grading score and micro‐CT) and chondrocyte senescence (indexed by levels of SA‐β‐gal, P16, P53, MMP13, ROS and ratio of healthy/collapsed mitochondrial membrane potentials). Network pharmacology and molecular docking suggested that AT‐III might play role through NF‐κB pathway. Further experiments revealed that AT‐III reduced phosphorylation of IKKα/β, IκBα and P65 in NF‐κB pathway. As well as nuclear translocation of p65. Both in vivo and in vitro experiments indicated that AT‐III's effects on osteoarthritis and anti‐senescence were reversed by an NF‐κB agonist. AT‐III could alleviate osteoarthritis by inhibiting chondrocyte senescence through NF‐κB pathway, which indicated that AT‐III is a prospective drug for osteoarthritis treatment.

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“…A chronic mild stress depression model, commonly used as the animal model of depression, has the greatest validity and translational potential with a similar phenotype, risk factors, and response to routine treatments used in MDD patients [ 113 ]. Various experiments show that chronic unpredictable mild stress leads to increased inflammation-related symptoms when induced in an animal model of depression [ 114 , 115 , 116 ], suggesting that inflammation may be an intermediate link between the mechanisms of depression. In another study, lipopolysaccharide (LPS) stimulation triggered central inflammation by mimicking acute inflammatory events, resulting in depressive-like behaviors [ 117 ].…”

Section: The Cornerstones Linking Inflammation and Depressionmentioning

confidence: 99%

Connexin 43: An Interface Connecting Neuroinflammation to Depression

et al. 2023

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Major depressive disorder (MDD) is a leading chronic mental illness worldwide, characterized by anhedonia, pessimism and even suicidal thoughts. Connexin 43 (Cx43), mainly distributed in astrocytes of the brain, is by far the most widely and ubiquitously expressed connexin in almost all vital organs. Cx43 forms gap junction channels in the brain, which mediate energy exchange and effectively maintain physiological homeostasis. Increasing evidence suggests the crucial role of Cx43 in the pathogenesis of MDD. Neuroinflammation is one of the most common pathological features of the central nervous system dysfunctions. Inflammatory factors are abnormally elevated in patients with depression and are closely related to nearly all links of depression. After activating the inflammatory pathway in the brain, the release and uptake of glutamate and adenosine triphosphate, through Cx43 in the synaptic cleft, would be affected. In this review, we have summarized the association between Cx43 and neuroinflammation, the cornerstones linking inflammation and depression, and Cx43 abnormalities in depression. We also discuss the significant association of Cx43 in inflammation and depression, which will help to explore new antidepressant drug targets.

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Atractylenolide III reduces depressive- and anxiogenic-like behaviors in rat depression models

Cited by 39 publications

References 26 publications

Utilization of functional agro-waste residues for oyster mushroom production: Nutritions and active ingredients in healthcare

Utilization of functional agro-waste residues for oyster mushroom production: Nutritions and active ingredients in healthcare

Atractylenolide‐III alleviates osteoarthritis and chondrocyte senescence by targeting NF‐κB signaling

Connexin 43: An Interface Connecting Neuroinflammation to Depression

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