Atractylodes lancea rhizome derived exosome-like nanoparticles prevent alpha-melanocyte stimulating hormone-induced melanogenesis in B16-F10 melanoma cells

Ishida, Tomoaki; Morisawa, Shumpei; Jobu, Kohei; Kawada, Kei; Yoshioka, Saburo; Miyamura, Mitsuhiko

doi:10.1016/j.bbrep.2023.101530

Biochemistry and Biophysics Reports

2023

DOI: 10.1016/j.bbrep.2023.101530

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Atractylodes lancea rhizome derived exosome-like nanoparticles prevent alpha-melanocyte stimulating hormone-induced melanogenesis in B16-F10 melanoma cells

Tomoaki Ishida,

Shumpei Morisawa,

Kohei Jobu

et al.

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2024

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Cited by 3 publications

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Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics

Ding,

Chang,

Liang

et al. 2024

Advanced Therapeutics

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Extracellular vesicles (EVs) are membranous structures secreted by cells that play important roles in intercellular communication and material transport. Due to its excellent biocompatibility, lipophilicity, and homing properties, EVs have been used as a new generation of drug delivery systems for the diagnosis and treatment of tumors. Despite the potential clinical benefits of animal‐derived extracellular vesicles (AEVs), their large‐scale production remains sluggish due to the exorbitant cost of cell culture, challenging quality control measures, and limited production capabilities. This constraint significantly hinders their widespread clinical application. Plant‐derived extracellular vesicles (PEVs) share similar functionalities with AEVs, yet they hold several advantages including a wide variety of source materials, cost‐effectiveness, ease of preparation, enhanced safety, more stable physicochemical properties, and notable efficacy. These merits position PEVs as promising contenders with broad potential in the biomedical sector. This review will elucidate the advantages of PEVs, delineating their therapeutic mechanisms in cancer treatment, and explore the prospective applications of engineered PEVs as targeted delivery nano‐system for drugs, microRNAs, small interfering RNAs, and beyond. The aim is to heighten researchers’ focus on PEVs and expedite the progression from fundamental research to the transformation of groundbreaking discoveries.

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Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics

Ding,

Chang,

Liang

et al. 2024

Advanced Therapeutics

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Plant‐derived nanovesicles offer a promising avenue for anti‐aging interventions

Meng,

Sun,

et al. 2024

Physiologia Plantarum

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Over the past few years, the study of plant‐derived nanovesicles (PDNVs) has emerged as a hot topic of discussion and research in the scientific community. This remarkable interest stems from their potential role in facilitating intercellular communication and their unique ability to deliver biologically active components, including proteins, lipids, and miRNAs, to recipient cells. This fascinating ability to act as a molecular courier has opened up an entirely new dimension in our understanding of plant biology. The field of research focusing on the potential applications of PDNVs is still in its nascent stages. However, it has already started gaining traction due to the growing interest in its possible use in various branches of biotechnology and medicine. Their unique properties and versatile applications offer promising future research and development prospects in these fields. Despite the significant progress in our understanding, many unanswered questions and mysteries surround the mechanisms by which PDNVs function and their potential applications. There is a dire need for further extensive research to elucidate these mechanisms and explore the full potential of these fascinating vesicles. As the technology at our disposal advances and our understanding of PDNVs deepens, it is beyond doubt that PDNVs will continue to be a subject of intense research in anti‐aging therapeutics. This comprehensive review is designed to delve into the fascinating and multifaceted world of PDNV‐based research, particularly focusing on how these nanovesicles can be applied to anti‐aging therapeutics.

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Plant-Derived Exosome-like Nanoparticles: A Comprehensive Overview of Their Composition, Biogenesis, Isolation, and Biological Applications

Sha,

Luo,

Xiao

et al. 2024

IJMS

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Plant-derived exosome-like nanoparticles (PELNs) are a type of membranous vesicle isolated from plant tissues. They contain proteins, lipids, nucleic acids, and other components. PELNs are involved in the defensive response to pathogen attacks by exerting anti-inflammatory, antiviral, antifibrotic, and antitumor effects through the substances they contain. Most PELNs are edible and can be used as carriers for delivering specific drugs without toxicity and side effects, making them a hot topic of research. Sources of PELNs are abundantly, and they can be produced in high yields, with a low risk of developing immunogenicity in vivo. This paper summarizes the formation, isolation, and purification methods; physical properties; and composition of PELNs through a comprehensive literature search. It also analyzes the biomedical applications of PELNs, as well as future research directions. This paper provides new ideas and methods for future research on PELNs.

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Atractylodes lancea rhizome derived exosome-like nanoparticles prevent alpha-melanocyte stimulating hormone-induced melanogenesis in B16-F10 melanoma cells

Cited by 3 publications

References 43 publications

Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics

Plant‐Derived Extracellular Vesicles as Potential Emerging Tools for Cancer Therapeutics

Plant‐derived nanovesicles offer a promising avenue for anti‐aging interventions

Plant-Derived Exosome-like Nanoparticles: A Comprehensive Overview of Their Composition, Biogenesis, Isolation, and Biological Applications

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