Atrial and brain natriuretic peptide in adrenal steroidogenesis

Atrial natriuretic peptide enhances cortisol secretion from guinea-pig adrenal gland: Evidence for an indirect paracrine mechanism probably involving the local release of medullary catecholamines

“…However, a direct action of ANP on zona fasciculatareticularis cells can be excluded, inasmuch as this peptide does not exert any cortisol secretagogue effect on dispersed cell preparations. In this connection, we wish to stress that this last observation is at variance with the reported direct inhibitory effect of ANP on the secretory activity of inner adrenocortical cells of other cortisol-secreting species, like cows and humans (7)(8)(9)(10)(11). Despite ineffective on inner adrenocortical cells, ANP is able to stimulate cortisol secretion from guinea pig adrenal slices containing medullary tissue.…”

“…Although ANF receptors have been demonstrated in the rat zona fasciculata (6), most studies did not report any effect of ANP on glucocorticoid secretion in this species (1,4). However, findings suggest that ANP is able to lower basal and especially ACTH-stimulated glucocorticoid production from cultured human and cow zona fasciculata cells (7,11). The A subtype of ANP receptors is expressed also in the adrenal medulla (12,13), and the bulk of evidence indicates that ANP inhibits catecholamine release (14-17).…”

Morphological and functional studies of the paracrine interaction between cortex and medulla in the adrenal gland

“…Moreover a whole series of neuropeptides have been identified in the adrenal medulla, which can stimulate steroid production, for example vasopressin and oxytocin (Gallo- Payet et al, 1986;Guillon et al, 1990Guillon et al, , 1995Hinson et al, 1987;Mazzocchi et al, 1993b;Payet and Lehoux, 1979;Payet et al, 1984;Perraudin et al, 1993;Woodcock et al, 1986), neuropeptide Y (Malendowicz, 1993;Malendowicz et al, 1990;Rebuffat et al, 1988a), substance P (Nussdorfer et al, 1988), and neuromedin N (Malendowicz, 1993;Malendowicz et al, 1993). 1993; Heisler et al, 1989;Higuchi et al, 1986;Nawata et al, 1991;Rá cz et al, 1985;Rebuffat et al, 1988b), the calcitonin gene-related peptide (Mazzocchi et al, 1992a;Murakami et al, 1989), dynorphin , and somatostatin (Rebuffat et al, 1994). Enkephalins, produced in relevant amounts in the adrenal medulla, similarly influence the adrenal cortex (Rá cz et al, 1980).…”

Urotensin-II and UII-receptor expression and function in the rat adrenal cortex

“…56,57). Although a large part of these peptides exert a secretagogue effect, others, in addition to AM (53), possess a marked inhibitory action: atrial natriuretic peptide (58)(59)(60)(61), neurotensin (62,63), leptin (64)(65)(66) and beacon (27,31,33,67). Our study provides the first evidence that UII may be included in this last group of peptides involved in the fine-tuning of adrenocortical secretion.…”