Atrial conduction times and left atrium mechanical functions in patients with active acromegaly

Abstract

The aim of this study was to evaluate atrial electromechanical delay (EMD), P wave dispersion (Pwd), and left atrial (LA) mechanical functions in patients with active acromegaly. Twenty-three patients with active acromegaly and 27 age- and sex-matched controls were included in this study. All atrial electromechanical interval parameters (PA lateral, PA septum, PA tricuspid, interatrial EMD, intra-LA EMD, and intra-right atrial EMD) were measured from mitral lateral annulus, mitral septal annulus, and right ventricular tricuspid annulus by tissue Doppler imaging. LA volumes were measured by the disk method in the apical four-chamber view and were indexed to the body surface area. Mechanical function parameters of LA were calculated. Pwd was performed by 12-lead electrocardiograms. Atrial electromechanical intervals (PA lateral, PA septum, PA tricuspid, interatrial EMD, intra-LA EMD, and intra-right atrial EMD) and Pwd were similar between patients with acromegaly and control subjects (all p > 0.05). LA volumes (maximum, minimum, and presystolic) and LA mechanical functions were not significantly different between the groups (all p > 0.05). Additionally, serum levels of growth hormone and insulin-like growth factor-1 were not correlated with atrial electromechanical parameters and LA mechanical functions. Atrial electrical conduction times were not prolonged and LA mechanical functions were not impaired in patients with active acromegaly compared with controls. And the prevalence of supraventricular arrhythmia risk may not increase in this population.

Three‐dimensional speckle tracking echocardiography–derived left atrial deformation analysis in acromegaly (Results from the MAGYAR‐Path Study)

“…In a recent study, LA volumes (maximum, minimum, and presystolic) and LA mechanical functions were not significantly different in patients with active acromegaly compared with age‐ and gender‐matched healthy controls. Additionally, serum levels of GH and IGF‐1 did not correlate with LA mechanical functions . A previous animal study examined 11 cats with acromegaly; 6 of the subject animals had significantly enlarged LA .…”

“…LVH and myocardial fibrosis are considered common findings in acromegalic cardiomyopathy in echocardiography studies . However, there is limited information on LA function in acromegaly …”

“…3DSTE is a validated method for left atrial (LA) quantification as compared to two‐dimensional (2D) echocardiography, 2DSTE, and volumetric real‐time 3D echocardiography (RT3DE) . The number of studies concerning acromegaly‐associated LA volumetric and functional changes is limited . The objective of this study was to investigate 3DSTE‐derived LA volumetric and functional properties in patients with acromegaly.…”

“…[6][7][8] The number of studies concerning acromegaly-associated LA volumetric and functional changes is limited. 9 The objective of this study was to investigate 3DSTE-derived LA volumetric and functional properties in patients with acromegaly. It was also examined whether the activity of acromegaly is associated with further alterations in these LA parameters.…”

Usefulness of Tissue Doppler-derived Atrial Electromechanical Delay for Identifying Patients with Paroxysmal Atrial Fibrillation

“…An increased left atrial (LA) volume index is also known as a strong predictor of AF [3][4][5]. It has been reported that the intra-and interatrial conduction time, that is, the atrial electromechanical delay (AEMD), is an index of reflecting pathological changes of the atria [6][7][8][9][10][11][12][13]. AEMD can be measured not only by invasive electrophysiologic study but also by echocardiographic tissue Doppler imaging (TDI) [7][8][9][10][11][12][13].…”