Atrial Electrophysiological Abnormality in Patients With Brugada Syndrome Assessed by P-Wave Signal-Averaged ECG and Programmed Atrial Stimulation

Yamada, Takeshi; Watanabe, Ichiro; Okumura, Yasuo; Takagi, Yasuhiro; Okubo, Kimie; Hashimoto, Kazuhito; Shindo, Atsushi; Nakai, Toshiko; Kasamaki, Yuji; Saito, Satoshi

doi:10.1253/circj.70.1574

Cited by 34 publications

(25 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[29][30][31][32] Thus, atrial repolarization abnormalities might contribute to the pathogenesis of AF in Brugada syndrome. In the present study, ERP-RA and RA MAPD 80 did not differ significantly between patients with Brugada syndrome and control patients, 9,14) but the MAP duration at the shortest diastolic interval was significantly shorter in the Brugada syndrome group than in the control group, and the maximum slope of the action potential restitution curve was significantly greater in the Brugada syndrome group than in the control group. We have reported that intravenous administration of quinidine increased RV MAPD 90 at the shortest diastolic interval and decreased the maximum slope of the RV action potential duration restitution curve.…”

Section: )contrasting

confidence: 54%

“…7) We reported previously that AF lasting > 30 seconds was induced in all patients with Brugada syndrome without spontaneous AF by a protocol using up to two extrastimuli from the high RA, and the mean ERP-RA at a cycle length of 600 ms in Brugada syndrome patients did not differ significantly from that in control patients. 14) Other studies involving a single extrastimulus yielded a much lower AF induction rate. Eckardt, et al 7) were able to induce AF in only 1 of 35 patients studied, although 9 others developed other supraventricular arrhythmias with a single atrial extrastimulus.…”

Section: )mentioning

confidence: 99%

“…Incidences of spontaneous atrial arrhythmias between 0% and 53% have been reported, [7][8][9][10][11][12][13][14][15][16][17][18] although the inducibility of atrial arrhythmia ranges from 3% to 100%. [7][8][9][10][11][12][13][14][15][16][17][18] Little is known about the relation between atrial arrhythmias and electrophysiologic backgrounds. We therefore compared depolarization and repolarization properties of the atria between patients with Brugada syndrome and control patients who underwent catheter ablation for tachyarrhythmias.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Abnormal Atrial Repolarization and Depolarization Contribute to the Inducibility of Atrial Fibrillation in Brugada Syndrome

et al. 2010

Self Cite

View full text Add to dashboard Cite

SummaryBrugada syndrome is often accompanied by atrial tachyarrhythmia, such as atrial fibrillation (AF). The aim of this study was to examine atrial vulnerability in patients with Brugada syndrome. Two groups of patients were compared: 18 patients with Brugada syndrome (Brugada syndrome group) and 11 age-matched patients with neither organic heart disease nor AF episodes (control group). Programmed electrical stimulation was performed from the right atrium (RA), and the effective refractory period of the right atrium (ERP-RA), interatrial conduction time (IACT), monophasic action potentials (MAPs) at the high RA, and the inducibility of AF lasting > 30 seconds were studied. MAP duration at 80% repolarization (MAPD 80 ) was calculated. AF was induced with a single extrastimulus or double extrastimuli in all patients with Brugada syndrome but in none of the control patients. The ERP-RA did not differ between the groups. IACT at the shortest diastolic interval was significantly increased in the Brugada syndrome group compared to that in the control group. The maximum slope of the MAPD 80 restitution curve was significantly steeper in the Brugada syndrome group than in the control group (2.4 ± 2.0 versus 0.82 ± 0.36, P < 0.02). Ventricular fibrillation was induced with ventricular programmed stimulation in all Brugada syndrome patients. Both abnormal interatrial conduction and steep restitution of action potential duration may contribute to the atrial arrhythmogenicity in Brugada syndrome. (Int Heart J 2010; 51: 159-165)

show abstract

Section: )contrasting

confidence: 54%

Section: )mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Abnormal Atrial Repolarization and Depolarization Contribute to the Inducibility of Atrial Fibrillation in Brugada Syndrome

et al. 2010

Self Cite

View full text Add to dashboard Cite

show abstract

“…Исследования показывают, что больные, не-сущие мутации в гене SCN5A, часто имеют уве-личение продолжительности P-волны и P-R-ин-тервала (200 мс и более), что отражает наличие задержки H-V-проводимости (55 мс и более) [32]. Эти данные позволяют предположить, что снижение натриевых деполяризующих токов влияет на внутрипредсердную скорость прове-дения и является возможным механизмом увели-чения продолжительности P-волны и P-R-ин-тервала у пациентов с синдромом Бругада.…”

Section: Discussionunclassified

Diagnostic’s experience and ten-year tretment outcomes of patients with brugada syndrome

Bockeria¹,

Pronicheva²,

Serguladze³

et al. 2017

Ann aritmol

View full text Add to dashboard Cite

“…We should therefore pay close attention to examining whether atrial fibrillation develops. Furthermore, a P-wave abnormality 19 and a high prevalence of sick sinus syndrome 20 complicated by BS indicate atrial involvement.…”

Section: Risk Determinantsmentioning

confidence: 99%

Risk Determinants in Individuals With a Spontaneous Type 1 Brugada ECG

Miyamoto

Hayashi

Makiyama

et al. 2011

Circ J

View full text Add to dashboard Cite

Background: Spontaneous coved ST-segment elevation ≥2 mm followed by a negative T-wave in the right precordial leads (type 1 Brugada ECG) is diagnostic of Brugada syndrome (BS), but there is a false-positive rate. Methods and Results:Computer-processed analysis of a 12-lead ECG database containing 49,286 females and 52,779 males was performed to select patients with a spontaneous type 1 Brugada ECG for an examination of the association of this ECG characteristic with long-term prognosis. There were 185 patients with a spontaneous type 1 Brugada ECG and of these, 16 (15 males; mean age, 46.7±14.0 years) were diagnosed with BS and 15 patients (all males; mean age, 50.1±13.4 years) were undiagnosed. The PQ interval was significantly longer in the diagnosed patients than in the undiagnosed patients (187.4±28.3 ms vs. 161.2±21.5 ms; P=0.0073). The T-wave in lead V1 was more negative in the diagnosed patients than in the undiagnosed patients (-170.2±174.6 μV vs. -43.2±122.3 μV, P=0.027). Multivariate analysis revealed that a PQ interval ≥170 ms and T-wave amplitude <−105 μV in lead V1 were independent risk stratifiers of life-threatening events. Survival analysis (mean follow-up, 78.6±81.8 months) showed that the PQ interval and a negative T-wave in lead V1 were significantly associated with poor prognosis. Conclusions:Analysis of a standard 12-lead ECG can stratify the prognosis of patients with a spontaneous type 1 Brugada ECG. (Circ J 2011; 75: 844 - 851)

show abstract

Atrial Electrophysiological Abnormality in Patients With Brugada Syndrome Assessed by P-Wave Signal-Averaged ECG and Programmed Atrial Stimulation

Cited by 34 publications

References 21 publications

Abnormal Atrial Repolarization and Depolarization Contribute to the Inducibility of Atrial Fibrillation in Brugada Syndrome

Abnormal Atrial Repolarization and Depolarization Contribute to the Inducibility of Atrial Fibrillation in Brugada Syndrome

Diagnostic’s experience and ten-year tretment outcomes of patients with brugada syndrome

Risk Determinants in Individuals With a Spontaneous Type 1 Brugada ECG

Contact Info

Product

Resources

About