Atrial Fibrillation and Cognitive Impairment: New Insights and Future Directions

Shamloo, Alireza Sepehri; Dagres, Nikolas; Müssigbrodt, Andreas; Stauber, Annina; Kircher, Simon; Richter, Sergio; Dinov, Boris; Bertagnolli, Livio; Husser-Bollmann, Daniela; Bollmann, Andreas; Hindricks, Gerhard; Arya, Arash

doi:10.1016/j.hlc.2019.05.185

Cited by 42 publications

(24 citation statements)

References 96 publications

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“…Epidemiological evidence indicates an association between AF, cognitive impairment and dementia [8,9,10,11,12,13]. The great impact of this issue is demonstrated by the several articles that have been published only in the last 12 months from the present review paper by Heart Rhythm Associations [14] and others [10,11,12,15,16,17,18,19,20,21,22]. Stroke-related AF is a well-known risk factor and predictor of cognitive impairment and dementia [23].…”

Section: Introductionmentioning

confidence: 86%

“…The relationship between AF and cognitive impairment/dementia has been reported in several studies [11,15,16,17,19,20,62,63]. The large cross-sectional Rotterdam Study was one of the first pieces of evidence to describe this association [64].…”

Section: Current “Views” On Atrial Fibrillation-related Strokementioning

confidence: 99%

“…In addition, a full understanding of the mechanisms by which AF may lead to cognitive impairment also in patients without any evidence of stroke remain not completely understood [33]. Cerebral hypoperfusion, chronic inflammation and endothelial dysfunction have been considered potentially involved in the pathogenesis of AF-cognitive impairment [11,20,34,35,36]. Currently, no therapeutic strategies are available to prevent cognitive dysfunction in stroke-free patients with AF; therefore, clarifying the potential underlying mechanisms of cognitive impairment in AF without stroke might be a critical issue.…”

Section: Introductionmentioning

confidence: 99%

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Cognitive Function and Atrial Fibrillation: From the Strength of Relationship to the Dark Side of Prevention. Is There a Contribution from Sinus Rhythm Restoration and Maintenance?

et al. 2019

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Atrial fibrillation (AF) is the most common chronic cardiac arrhythmia with an increasing prevalence over time mainly because of population aging. It is well established that the presence of AF increases the risk of stroke, heart failure, sudden death, and cardiovascular morbidity. In the last two decades several reports have shown an association between AF and cognitive function, ranging from impairment to dementia. Ischemic stroke linked to AF is a well-known risk factor and predictor of cognitive decline. In this clinical scenario, the risk of stroke might be reduced by oral anticoagulation. However, recent data suggest that AF may be a predictor of cognitive impairment and dementia also in the absence of stroke. Cerebral hypoperfusion, reduced brain volume, microbleeds, white matter hyperintensity, neuroinflammation, and genetic factors have been considered as potential mechanisms involved in the pathogenesis of AF-related cognitive dysfunction. However, a cause-effect relationship remains still controversial. Consequently, no therapeutic strategies are available to prevent AF-related cognitive decline in stroke-free patients. This review will analyze the potential mechanisms leading to cognitive dysfunction in AF patients and examine the available data on the impact of a sinus rhythm restoration and maintenance strategy in reducing the risk of cognitive decline.

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Section: Introductionmentioning

confidence: 86%

Section: Current “Views” On Atrial Fibrillation-related Strokementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cognitive Function and Atrial Fibrillation: From the Strength of Relationship to the Dark Side of Prevention. Is There a Contribution from Sinus Rhythm Restoration and Maintenance?

et al. 2019

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“… 258 , 259 Multiple risk factors for dementia have been identified in the general population, including modifiable and non-modifiable ones. 269 Apart from these AF-non-specific risk factors, AF may lead to cognitive impairment by multiple mechanisms. These include apparent stroke, silent stroke but also other mechanisms that are independent of thromboembolism.…”

Section: How To Assess Risk For Adverse Outcomes In Patients With Atrmentioning

confidence: 99%

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population

et al. 2020

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“…Another major adverse effect of AF is impairment of cognitive function 258,259 . Multiple risk factors for dementia have been identified in the general population, including modifiable and non‐modifiable ones 269 . Apart from these AF‐non‐specific risk factors, AF may lead to cognitive impairment by multiple mechanisms.…”

Section: How To Assess Risk For Adverse Outcomes In Patients With Atrmentioning

confidence: 99%

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population

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Lin

Figueiredo

et al. 2020

Journal of Arrhythmia

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Atrial Fibrillation and Cognitive Impairment: New Insights and Future Directions

Cited by 42 publications

References 96 publications

Cognitive Function and Atrial Fibrillation: From the Strength of Relationship to the Dark Side of Prevention. Is There a Contribution from Sinus Rhythm Restoration and Maintenance?

Cognitive Function and Atrial Fibrillation: From the Strength of Relationship to the Dark Side of Prevention. Is There a Contribution from Sinus Rhythm Restoration and Maintenance?

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population

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