Atrial fibrillation and survival in colorectal cancer

Walsh, Stewart R.; Gladwish, Kelly M; Ward, Nicholas J; Justin, Timothy A.; Keeling, Neil

doi:10.1186/1477-7819-2-40

Cited by 16 publications

(13 citation statements)

References 15 publications

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“…The remaining articles were screened, and 3487 were subsequently excluded because they were review articles, animal studies, or irrelevant to this analysis. The 28 remaining studies were then reviewed in detail, and 23 of the 28 were excluded: study published in Italian, Russian, or Spanish language ( n =5) [13–16]; study reported AF leading to cancer ( n =4) [17–20]; individual case reports ( n =3) [21–23]; letters [24, 25] or editorials [26] ( n =3); different article from the same center [27, 28], and a more recent series was available [8], patients in this study [29] may be repeated in the study by Conen [10] ( n =3); study evaluated the relation of AF and survival in cancer patients ( n =2) [30, 31]; OR was not provided ( n =1) [32]; cross-sectional study ( n =1) [33]; and study investigated AF as a complication in cancer patients ( n =1) [34]. Therefore, a total of five studies comprising 5,889,234 participants were included in our meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis

Yuan

Zhang

Tse

et al. 2019

Cardiology Research and Practice

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Aims. Previous studies have demonstrated epidemiological evidence for an association between cancer and the development of new-onset atrial fibrillation (AF). However, these results have been conflicting. This systematic review and meta-analysis was conducted to examine the relationship between cancer and the risk of developing atrial fibrillation. Methods. PubMed and Web of Science were searched for publications examining the association between cancer and atrial fibrillation risk published until June 2017. Adjusted odds ratios (ORs) or hazard ratios (HRs) and 95% CI were extracted and pooled. Results. A total of five studies involving 5,889,234 subjects were included in this meta-analysis. Solid cancer patients are at higher risk developing atrial fibrillation compared to noncancer patients (OR 1.47, 95% CI 1.31 to 1.66, p<0.00001; I2 = 67%, p=0.02). The risk of atrial fibrillation was highest within 90 days of cancer diagnosis (OR 7.62, 95% CI 3.08 to 18.88, p<0.00001) and this risk diminished with time. Conclusions. The risk of AF was highest within 90 days of cancer diagnosis. We should take into account the increased risk of atrial fibrillation development and, after this, study the embolic risk and potential indication of oral anticoagulation.

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Section: Resultsmentioning

confidence: 99%

Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis

Yuan

Zhang

Tse

et al. 2019

Cardiology Research and Practice

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“…AF was also associated with higher long-term mortality among patients alive at 5 years from surgery (HR 3.75, 95% CI 1.44-9.08, p = 0.007) 14 . In patients who underwent surgery for CRC, AF seems also to indicate worse survival 15 .…”

Section: Resultsmentioning

confidence: 99%

Atrial Fibrillation and Non-cardiovascular Diseases: A Systematic Review

Ferreira¹,

Providência²,

Ferreira³

et al. 2015

Arquivos Brasileiros De Cardiologia

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Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with an unfavorable prognosis, increasing the risk of stroke and death. Although traditionally associated with cardiovascular diseases, there is increasing evidence of high incidence of AF in patients with highly prevalent noncardiovascular diseases, such as cancer, sepsis, chronic obstructive pulmonary disease, obstructive sleep apnea and chronic kidney disease. Therefore, considerable number of patients has been affected by these comorbidities, leading to an increased risk of adverse outcomes.The authors performed a systematic review of the literature aiming to better elucidate the interaction between these conditions.Several mechanisms seem to contribute to the concomitant presence of AF and noncardiovascular diseases. Comorbidities, advanced age, autonomic dysfunction, electrolyte disturbance and inflammation are common to these conditions and may predispose to AF.The treatment of AF in these patients represents a clinical challenge, especially in terms of antithrombotic therapy, since the scores for stratification of thromboembolic risk, such as the CHADS2 and CHA2DS2VASc scores, and the scores for hemorrhagic risk, like the HAS-BLED score have limitations when applied in these conditions.The evidence in this area is still scarce and further investigations to elucidate aspects like epidemiology, pathogenesis, prevention and treatment of AF in noncardiovascular diseases are still needed.

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“…Numerous reports have suggested a higher risk of cancer following an AF diagnosis. 15,16,17,18,19,20 Many reports have focused on colorectal cancer with conflicting findings, 8,9,10,13,20 suggesting that this association may reflect detection bias (eg, malignant neoplasm being unmasked by greater health care contact or bleeding in patients starting anticoagulation therapy after an AF diagnosis). In the present study, we did not observe a higher risk of AF preceding the breast cancer diagnosis relative to that in matched cancer-free controls.…”

Section: Discussionmentioning

confidence: 99%

“…The growing interest in cardio-oncology (the field of cardiovascular disease in patients with cancer) 1,2,3 has been accompanied by concerns about an increased risk of developing atrial fibrillation (AF) following cancer diagnosis, 4,5,6,7,8,9,10,11,12,13,14,15 as well as a higher risk of cancer following the recognition of AF. 15,16,17,18,19,20 In fact, AF has been proposed as a marker of an occult malignant neoplasm.…”

Section: Introductionmentioning

confidence: 99%

Association of Early-Stage Breast Cancer and Subsequent Chemotherapy With Risk of Atrial Fibrillation

et al. 2019

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Atrial fibrillation and survival in colorectal cancer

Abstract: Background: Survival in colorectal cancer may correlate with the degree of systemic inflammatory response to the tumour. Atrial fibrillation may be regarded as an inflammatory complication. We aimed to determine if atrial fibrillation is a prognostic factor in colorectal cancer.

Cited by 16 publications

References 15 publications

Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis

Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis

Atrial Fibrillation and Non-cardiovascular Diseases: A Systematic Review

Association of Early-Stage Breast Cancer and Subsequent Chemotherapy With Risk of Atrial Fibrillation

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