Atrial Fibrillation Hospitalization Is Not Increased with Short‐Term Elevations in Exposure to Fine Particulate Air Pollution

Bunch, T. Jared; Horne, Michael; Asirvatham, Samuel J.; Day, John D.; Crandall, Brian G.; Weiss, J. Peter; Osborn, Jeffrey S.; Anderson, Jeffrey L.; Muhlestein, Joseph B; Lappé, Donald; Pope, C. Arden

doi:10.1111/j.1540-8159.2011.03200.x

Cited by 42 publications

(39 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Researchers have reported alterations in heart-rate intervals associated with variations in ambient levels of air pollution, particularly in individuals with high levels of markers of oxidative stress and systemic inflammation. 92 However, pollutant-induced ventricular arrhythmia 90,93 and atrial fibrillation 50,94 have been predominantly detected in people with existing cardiac disease. In addition, the results of controlled-inhalation studies have shown no short-term risk of arrhythmia in healthy adults, suggesting that the association between pollution and the risk of cardiac rhythm disturbances is limited to highly susceptible individuals.…”

Section: Blood Pressure and Vascular Functionmentioning

confidence: 99%

Environmental factors in cardiovascular disease

2015

View full text Add to dashboard Cite

Environmental exposure is an important but underappreciated risk factor contributing to the development and severity of cardiovascular disease (CVD). The heart and vascular system are highly vulnerable to a number of environmental agents--ambient air pollution and the metals arsenic, cadmium, and lead are widespread and the most-extensively studied. Like traditional risk factors, such as smoking and diabetes mellitus, these exposures advance disease and mortality via augmentation or initiation of pathophysiological processes associated with CVD, including blood-pressure control, carbohydrate and lipid metabolism, vascular function, and atherogenesis. Although residence in highly polluted areas is associated with high levels of cardiovascular risk, adverse effects on cardiovascular health also occur at exposure levels below current regulatory standards. Considering the widespread prevalence of exposure, even modest contributions to CVD risk can have a substantial effect on population health. Evidence-based clinical and public-health strategies aimed at reducing environmental exposures from current levels could substantially lower the burden of CVD-related death and disability worldwide.

show abstract

Section: Blood Pressure and Vascular Functionmentioning

confidence: 99%

Environmental factors in cardiovascular disease

2015

View full text Add to dashboard Cite

show abstract

“…Likewise, epidemiological studies have failed to show a relationship between permanently higher fine particle ex-posure and AF incidence 158,159 (Table 8). Short-term exposure may directly enhance AF susceptibility in patients with cardiac disease.…”

Section: Introductionmentioning

confidence: 99%

European Heart Rhythm Association (EHRA)/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS)

Görenek

Pelliccia

Benjamin

et al. 2016

Eur J Prev Cardiolog

View full text Add to dashboard Cite

show abstract

“…Among patients with coronary heart disease and elderly participants, increasing exposure to PM air pollution increased the incidence of asymptomatic runs of supraventricular arrhythmias in two observational studies (Berger et al 2006; Sarnat et al 2006). However, in a recent robust case-crossover study of > 10,000 admissions to hospital with AF, there was no association with PM air pollution (Bunch et al 2011). A more recent prospective analysis of patients with implantable cardiac defibrillators with established cardiac disease showed an increased risk of AF with acute increases in exposure to PM air pollution (Link et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Controlled Exposures to Air Pollutants and Risk of Cardiac Arrhythmia

Langrish

Watts

Hunter

et al. 2014

Environ Health Perspect

View full text Add to dashboard Cite

Background: Epidemiological studies have reported associations between air pollution exposure and increases in cardiovascular morbidity and mortality. Exposure to air pollutants can influence cardiac autonomic tone and reduce heart rate variability, and may increase the risk of cardiac arrhythmias, particularly in susceptible patient groups.Objectives: We investigated the incidence of cardiac arrhythmias during and after controlled exposure to air pollutants in healthy volunteers and patients with coronary heart disease.Methods: We analyzed data from 13 double-blind randomized crossover studies including 282 participants (140 healthy volunteers and 142 patients with stable coronary heart disease) from whom continuous electrocardiograms were available. The incidence of cardiac arrhythmias was recorded for each exposure and study population.Results: There were no increases in any cardiac arrhythmia during or after exposure to dilute diesel exhaust, wood smoke, ozone, concentrated ambient particles, engineered carbon nanoparticles, or high ambient levels of air pollution in either healthy volunteers or patients with coronary heart disease.Conclusions: Acute controlled exposure to air pollutants did not increase the short-term risk of arrhythmia in participants. Research employing these techniques remains crucial in identifying the important pathophysiological pathways involved in the adverse effects of air pollution, and is vital to inform environmental and public health policy decisions.Citation: Langrish JP, Watts SJ, Hunter AJ, Shah AS, Bosson JA, Unosson J, Barath S, Lundbäck M, Cassee FR, Donaldson K, Sandström T, Blomberg A, Newby DE, Mills NL. 2014. Controlled exposures to air pollutants and risk of cardiac arrhythmia. Environ Health Perspect 122:747–753; http://dx.doi.org/10.1289/ehp.1307337

show abstract

Atrial Fibrillation Hospitalization Is Not Increased with Short‐Term Elevations in Exposure to Fine Particulate Air Pollution

Cited by 42 publications

References 21 publications

Environmental factors in cardiovascular disease

Environmental factors in cardiovascular disease

European Heart Rhythm Association (EHRA)/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS)

Controlled Exposures to Air Pollutants and Risk of Cardiac Arrhythmia

Contact Info

Product

Resources

About