Atrial fibrillation in patients with SARS-CoV-2 infection

Prevalence and Impact of Atrial Fibrillation in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis

“…Of the 783 studies identified from the literature search (216 on Pubmed and 567 on EMBASE), 31 studies were selected according to the inclusion and exclusion criteria and included in the analysis [ 3 , 10 , 11 , 12 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ] ( Figure S1 in Supplementary Materials ), with a total of 187,716 COVID-19 patients. Baseline characteristics of the studies included are reported in Table 1 .…”

“…Thirteen studies were held in Europe [ 10 , 11 , 25 , 29 , 31 , 33 , 37 , 39 , 42 , 43 , 44 , 47 , 50 ], nine in North America [ 3 , 28 , 30 , 32 , 41 , 45 , 46 , 49 , 51 ], four in Asia [ 26 , 34 , 35 , 48 ], and five in other geographical locations, including one multinational study [ 12 , 27 , 36 , 38 , 40 ]. Twenty-five studies were observational retrospective [ 3 , 10 , 12 , 26 , 28 , 30 , 31 , 32 , 34 , 35 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ], four were based on prospective observational analysis of single center cohorts [ 11 , …”

“…Of the studies, 14 were included in the analysis for all-cause mortality according to AF status (12 reported in-hospital death [ 3 , 10 , 12 , 25 , 29 , 30 , 37 , 40 , 41 , 42 , 43 , 45 ] and two described 30-day mortality [ 32 , 50 ]). Nine studies included patients with new onset AF [ 10 , 29 , 36 , 37 , 40 , 41 , 42 , 45 , 51 ].…”

“…We compared several baseline characteristics and conditions between patients presenting with and without AF. Eight studies reported data disaggregated by AF diagnosis on proportion of female sex, hypertension, and diabetes [ 10 , 29 , 30 , 37 , 40 , 41 , 43 , 45 ]; seven reported about mean age [ 10 , 29 , 30 , 37 , 40 , 43 , 45 ] and CHF [ 10 , 29 , 30 , 40 , 41 , 43 , 45 ], while six reported on CAD [ 10 , 29 , 30 , 41 , 43 , 45 ]; finally, 12 reported on proportion of critical patients [ 3 , 26 , 29 , 30 , 35 , 37 , 40 , 41 , 45 , 48 , 49 ] (specifically, six according to ICU admission [ 3 , 26 , 29 , 30 , 43 , 49 ], two according to “critically ill” definition [ 35 , 48 ], one according to ICU/intermediate care unit admission [ 37 ], and two according to patients receiving mechanical ventilation [ 41 , 45 ]).…”

“…Subgroup analyses according to the outcome definition are reported in Figure S4 . Twelve studies reported in-hospital death [ 3 , 10 , 12 , 25 , 29 , 30 , 37 , 40 , 41 , 42 , 43 , 45 ] and two reported 30-days mortality [ 32 , 50 ]. Patients with AF showed both higher risk of in-hospital mortality (OR 3.52, 95% CI 2.44–5.10) and 30-days mortality (OR 7.34, 95% CI: 3.11–17.34), with no statistically significant difference between subgroups ( p = 0.12; Figure S4 ).…”