Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER) study design

Ertaş, Faruk; Kaya, Hasan; Yüksel, Murat; Soydinç, Mehmet Serdar; Alan, Sait; Ülgen, Mehmet Sıddık

doi:10.5152/akd.2013.073

Cited by 10 publications

(23 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first epidemiologic registry about non-valvular AF was started in Turkey with the AFTER study (15). In the AFTER study, it was shown that the TTR level was detected in 41.3% of the patients with AF in Turkey (16).…”

Section: Discussionmentioning

confidence: 99%

The awareness, efficacy, safety, and time in therapeutic range of warfarin in the Turkish population: warfarin -tr

Çelik¹,

İzcı²,

Kobat³

et al. 2015

Anatol J Cardiol

View full text Add to dashboard Cite

Objective:The awareness, time in therapeutic range (TTR), and safety of warfarin therapy were investigated in the adult Turkish population.Methods:This multicenter prospective study includes 4987 patients using warfarin and involved regular international normalized ratio (INR) monitoring between January 1, 2014 and December 31, 2014. TTR was calculated according to F.R. Roosendaal’s algorithm. Awareness was evaluated based on the patients’ knowledge of warfarin’s affect and food–drug interactions.Results:The mean TTR of patients was 49.52±22.93%. The patients with hypertension (55.3%), coronary artery disease (23.2%), congestive heart failure (24.5%), or smoking habit (20.8%) had significantly lower TTR levels than the others. Of the total number of patients, 42.6% had a mechanical valve, 38.4% had non-valvular atrial fibrillation (AF), and 19% had other indications for warfarin. Patients with other indications had lower TTR levels than those with mechanical valve and non-valvular AF (p=0.018). Warfarin awareness decreased in higher age groups. The knowledge of warfarin’s food–drug interactions was 55%. People with higher warfarin awareness had higher TTR levels. Patients with ≤8 INR monitoring/year had lower TTR levels (46.4±25.3 vs. 51.1±21.3, respectively, p<0.001) and lower awareness (44.6% vs. 60.6%, p<0.001) than patients with ≥8 INR monitoring/year. In this study, 20.1% of the patients had a bleeding event (major bleeding 15.8%, minor bleeding 84.2%) within a year.Conclusion:Both the mean TTR ratios and awareness of the Turkish population on warfarin therapy were found to be low. It was thought that low TTR levels of the Turkish population may be caused by the low awareness of warfarin, warfarin’s food–drug interactions, and high rates of concomitant diseases. (Anatol J Cardiol 2016; 16: 595-600)

show abstract

Section: Discussionmentioning

confidence: 99%

The awareness, efficacy, safety, and time in therapeutic range of warfarin in the Turkish population: warfarin -tr

Çelik¹,

İzcı²,

Kobat³

et al. 2015

Anatol J Cardiol

View full text Add to dashboard Cite

show abstract

“…There are several predictors of PAF, such as hypertension, heart failure, valvular heart disease, and hyperthyroidism (14, 15). In our previous multicenter study, the Atrial Fibrillation Registry in Turkey (AFTER), we found that hypertension was the most common comorbid condition in patients with AF (16, 17). In fact, an increased P wave duration on standard 12-lead ECG indicates the presence of an atrial conduction disorder (18).…”

Section: Discussionmentioning

confidence: 99%

The relationship between atrial electromechanical delay and left atrial mechanical function in stroke patients

Akıl¹,

Akıl²,

Bilik³

et al. 2015

Anatol J Cardiol

Self Cite

View full text Add to dashboard Cite

Objective:The aim of this study was to evaluate the relationship between atrial electromechanical delay (EMD) measured with tissue Doppler imaging (TDI) and left atrial (LA) mechanical functions in patients with ischemic stroke and compare them with healthy controls.Methods:Thirty patients with ischemic stroke were enrolled into this cross-sectional, observational study. The control group consisted of 35 age- and gender-matched apparently healthy individuals patients. Acute cerebral infarcts of probable embolic origin were diagnosed via imaging and were confirmed by a neurologist. Echocardiographically, time intervals from the beginning of P wave to beginning of A wave from the lateral and septal mitral and right ventricular tricuspid annuli in TDI were recorded. The differences between these intervals gave the mechanical delays (inter- and intra-atrial). Left atrial (LA) volumes were measured using the biplane area-length method, and LA mechanical function parameters were calculated. Statistical analysis was performed using student’s t-test, chi-squared test, and Pearson’s test.Results:The laboratory and clinical characteristics were similar in the two groups. Increased left atrial EMD (21.36±10.38 ms versus 11.74±6.06 ms, p<0.001), right atrial EMD (13.66±8.62 ms versus 9.66±6.81 ms, p=0.040), and interatrial EMD (35.03±9.95 ms versus 21.40±8.47 ms, p<0.001) were observed in stroke patients as compared to controls. Active LA emptying volume and fraction and passive LA emptying volumes and fraction were similar between controls and stroke patients. Total LA emptying volumes were significantly increased in stroke patients as compared to healthy controls (33.19±11.99 mL/m2 versus 27.48±7.08 mL/m2, p=0.021).Conclusion:According to the results of our study, interatrial electromechanical delay may be a new predictor for ischemic stroke.

show abstract

“…They were included in the study in a manner of refl ecting the population of all geographic regions of Turkey [11]. These centers were interviewed and informed about the number of patients that they should admit to the study according to the population of the city.…”

Section: Study Design and Patient Selectionmentioning

confidence: 99%

The Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER)

Ertaş

Eren²,

Kaya

et al. 2013

Cardiol J

Self Cite

View full text Add to dashboard Cite

years (56% female). Persistent-permanent AF was found to be the most common type of non-valvular AF (78%). The most common comorbid disorder was hypertension (73%). It was found that oral anticoagulant therapy was used by 40% of all patients, 37% of whom had effective INR (2.0-3.0). Upon multivariate analysis, age was found to be the only independent predictor of stroke among the variables' effects on thromboembolic events that created CHA 2 DS 2 -VASc abbreviations (OR 1.026, p < 0.001). Conclusions: These results suggest that stroke risk scores should be thoroughly heeded based on guidelines, and that anticoagulation must be applied according to their guidance. (Cardiol J 2013; 20, 4: 447-452)

show abstract

Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER) study design

Cited by 10 publications

References 11 publications

The awareness, efficacy, safety, and time in therapeutic range of warfarin in the Turkish population: warfarin -tr

The awareness, efficacy, safety, and time in therapeutic range of warfarin in the Turkish population: warfarin -tr

The relationship between atrial electromechanical delay and left atrial mechanical function in stroke patients

The Atrial Fibrillation in Turkey: Epidemiologic Registry (AFTER)

Contact Info

Product

Resources

About