2019
DOI: 10.1002/clc.23284
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Atrial fibrillation‐related stroke in women: Evidence and inequalities in epidemiology, mechanisms, clinical presentation, and management

Abstract: BackgroundAtrial fibrillation (AF) is the most common clinical arrhythmia and one of the major causes of stroke, heart failure, sudden death, and cardiovascular morbidity. Despite substantial advances in (interventional) rhythm control treatment during the last decade, anticoagulation for stroke prevention remains a major component of AF treatment.HypothesisThere are important sex‐specific differences in AF‐related stroke, resulting from sex‐specific mechanisms and therapeutic differences.MethodsThis review su… Show more

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Cited by 24 publications
(19 citation statements)
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“…Thus, pharmacological therapies of cardiac arrhythmias should be focused on the most relevant underlying mechanism of arrhythmias, where it's known, and interventions may be antiarrhythmic by suppressing the initiating arrhythmogenic mechanism. Atrial fibrillation (AF) is caused by various mechanisms and one of the most common cardiac rhythm disturbances (Chua et al, 2019;Sutanto et al, 2019) associated with increased risk of heart failure, stroke (Kostopoulou et al, 2019), and death. More than dozens of genetic loci have been associated with AF, but the current review does not attempt to focus on these genetic mechanisms (Kalsto et al, 2019) and clinical management (Sutanto et al, 2019) of AF in detail.…”
Section: The Heart and Arrhythmiasmentioning
confidence: 99%
“…Thus, pharmacological therapies of cardiac arrhythmias should be focused on the most relevant underlying mechanism of arrhythmias, where it's known, and interventions may be antiarrhythmic by suppressing the initiating arrhythmogenic mechanism. Atrial fibrillation (AF) is caused by various mechanisms and one of the most common cardiac rhythm disturbances (Chua et al, 2019;Sutanto et al, 2019) associated with increased risk of heart failure, stroke (Kostopoulou et al, 2019), and death. More than dozens of genetic loci have been associated with AF, but the current review does not attempt to focus on these genetic mechanisms (Kalsto et al, 2019) and clinical management (Sutanto et al, 2019) of AF in detail.…”
Section: The Heart and Arrhythmiasmentioning
confidence: 99%
“…In the Global Burden of Disease Study (2010), age‐adjusted prevalence (per 100.000 population) of AF was 596.2 in men versus 373.1 in women; and incidence (per 100.000 population) was 77.5 in men versus 59.5 in women 108 . However, women had a higher risk of AF‐associated stroke and mortality compared with men 108,109 . Compared with men, women are less likely to receive OAC at all levels of the CHA2DS2VASc score 110 .…”
Section: Race and Sex‐based Disparities In Management Of Structural Heart Diseasementioning
confidence: 97%
“…The women aged < 65 years with 'lone' AF have a low annual risk for stroke; therefore, the current European and American guidelines do not recommend anticoagulation therapy for this group [12,13]. In a meta-analysis of 30 studies with 4371714 participants, Edim CA and al.…”
Section: Af and Stroke In Womenmentioning
confidence: 99%
“…found AF to be a significant risk factor for death and cardiovascular disease, more important in women than in men [14]. When AF associates with stroke, cardiac events, and heart failure, all causes mortality, is more pronounced in women than men [8,13], suggesting that women and men experience risk factors for cardiovascular disease differently [8,15]. It is unclear what could cause these differences.…”
Section: Af and Stroke In Womenmentioning
confidence: 99%