2019
DOI: 10.1016/j.jacbts.2019.05.005
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Atrial Myopathy

Abstract: HighlightsThe authors discuss the concept of atrial myopathy; its relationship to aging, electrophysiological remodeling, and autonomic remodeling; the interplay between atrial myopathy, AF, and stroke; and suggest how to identify patients with atrial myopathy and how to incorporate atrial myopathy into decisions about anticoagulation.Atrial myopathy seen in animal models of AF and in patients with AF is the result of a combination of factors that lead to electrical and structural remodeling in the atrium. Alt… Show more

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Cited by 165 publications
(169 citation statements)
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References 142 publications
(166 reference statements)
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“…Indeed, risk stratification as "risk of AF" by the AA was associated with coronary artery disease and congestive heart failure, both common clinical risk factors of atrial cardiopathy. 27,28 This suggests that the AA-based risk stratification used here could potentially aid in detecting electrical changes within the left atrium associated with atrial cardiopathy.…”
Section: Discussionmentioning
confidence: 96%
“…Indeed, risk stratification as "risk of AF" by the AA was associated with coronary artery disease and congestive heart failure, both common clinical risk factors of atrial cardiopathy. 27,28 This suggests that the AA-based risk stratification used here could potentially aid in detecting electrical changes within the left atrium associated with atrial cardiopathy.…”
Section: Discussionmentioning
confidence: 96%
“…The authors considered atrial remodelling as the initial cardiomyocyte response to various stressors (pressure and/or volume overload, arrhythmias), such as electrical and structural remodelling in response to repeated arrhythmic events (atrial fibrillation) with resulting changes in atrial geometry (size and sphericity), function and electrophysiology. Atrial cardiomyopathy translates into a diseased and fibrotic myocardium, with a subsequent risk of developing heart failure and atrial dysfunction [11][12][13]. The previously attempted classifications of atrial cardiomyopathies are, however, rarely used in clinical practice, since it is mostly histological-based and hard to implement in day-to-day clinical practice [5,11].…”
Section: Atrial Cardiomyopathy and Left Atrial Remodellingmentioning
confidence: 99%
“…The most clinically important cardiac arrhythmias, atrial fibrillation and ventricular fibrillation, are invariably associated with significant underlying heart disease [1,2]. One of the major difficulties with managing these arrhythmias is that despite often decades of progressive heart disease these arrhythmias have an abrupt onset that cannot be predicted in advance [2,21].…”
Section: Impact Of Disease Progressionmentioning
confidence: 99%
“…Cardiac arrhythmias, which impair the heart's ability to pump blood effectively, are a major cause of morbidity [1] and mortality [2]. Arrhythmic activity is underpinned by re-entrant rotors of electrical activity in the myocardium [3][4][5][6].…”
Section: Introductionmentioning
confidence: 99%
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