Atrial Natriuretic Factor: A Hormone Produced by the Heart

Bold, Adolfo J. de

doi:10.1126/science.2932797

Cited by 950 publications

(309 citation statements)

References 54 publications

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“…3 Human atrial natriuretic peptide (hANP), a 28-aminoacid peptide hormone secreted predominantly by atrial cardiomyocytes, has diuretic, natriuretic, vasodilatory, aldosterone-inhibitory, and arterial BP-reducing effects. 4,5 Numerous physiological responses to exogenous ANP include a rapid natriuresis, diuresis and reduction in arterial BP in hypertensive laboratory animals and humans. 6 These findings suggest that ANP exerts a broad spectrum of beneficial effects for the treatment of hypertension, renal impairment and heart failure.…”

Section: Introductionmentioning

confidence: 99%

Circadian renal rhythms influenced by implanted encapsulated hANP-producing cells in Goldblatt hypertensive rats

Chen

Wan

et al. 2004

Gene Ther

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Renal excretion in experimental hypertensive rats implanted with encapsulated human atrial natriuretic peptide (hANP)-producing cells is circadian periodic. Chinese hamster ovary (CHO) cells transfected with the plasmid hANP-cDNA were encapsulated in biocompatible polycaprolactone capsules for intraperitoneal implantation into two-kidney, one-clip (2K1C) hypertensive rats. During a 12:12 light-dark cycle, as compared to control CHO cells, the implantation of encapsulated hANPproducing CHO cells was associated with an increase in the net excretion of water, sodium and potassium, and with a reversal of the advanced circadian phases related to renovascular hypertension in 2K1C rats. The increase in blood pressure postimplantation was delayed, and increases in renal blood flow, glomerular filtration rate, sodium output, urinary excretion and urinary cyclic GMP concentrations were also found. Implantation of encapsulated hANP-producing cells affects circadian rhythms in kidney excretion functions of 2K1C rats, and may be useful for the treatment of cardiovascular disease.

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Section: Introductionmentioning

confidence: 99%

Circadian renal rhythms influenced by implanted encapsulated hANP-producing cells in Goldblatt hypertensive rats

Chen

Wan

et al. 2004

Gene Ther

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“…Atrial natriuretic peptide is a novel hormone involved in the regulation of water and electrolyte homeostasis [1]. Quantitatively the most important source of ANP is the heart atria [2] but ANP has also been extracted from the heart ventricles [3,4], brain [2,5], eyes [6], adrenal gland [7], pituitary, lungs [8] and blood vessels [9].…”

Section: Introductionmentioning

confidence: 99%

Atrial natriuretic peptide (ANP) in rat gastrointestinal tract

et al. 1988

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Acid extracts of rat stomach and small intestine contained 8.6 + 3.7 and 39 + 15 ng/g ofimmunoreactive atrial natriuretic peptide (ANP). When studied by gel filtration and reverse-phase high-performance liquid chromatography, the stomach immunoreactivity consisted of multiple components, whereas the small intestine contained mostly proANP and ANP 1-28-like material. These findings indicate that ANP may have a role in the physiology of the gastrointestinal tract, e.g. in the regulation of water and electrolyte absorption.

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“…6 Zimmerman et al reported that when α-ANP was infused exogenously at the lowest infusion rate in anesthetized dogs, the circulating α-ANP levels (increased to 31 ± 3 pg·mL -1 ) resulted in an increase of urine flow with no change in hemodynamic state. 7 Thus, it is possible that the increased plasma α-ANP levels exerted a diuretic action without any hemodynamic change in the present study.…”

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confidence: 99%

High frequency jet ventilation is associated with increased levels of plasma α-atrial natriuretic peptide — a preliminary study

Nagatani

Niiya²,

Sumikawa

2002

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : To determine if high frequency jet ventilation (HFJV) influences the secretion of α-atrial natriuretic peptide (α-ANP).M Me et th ho od ds s: : Sixteen patients undergoing otolaryngeal surgery were studied. Nine patients were subjected to intermittent positive pressure ventilation (IPPV), and seven patients underwent HFJV. Blood samples were drawn for the measurement of plasma α-ANP levels and blood gases before anesthesia, and at 30-min after starting either type of ventilation. The study was started at 2:00 p.m., and was completed before surgery. The plasma concentration of α-ANP was assayed by radioimmunoassay.R Re es su ul lt ts s: : There were no significant differences in mean arterial pressure, heart rate, oxygenation index and PaCO 2 between the two groups. IPPV was not associated with any changes in plasma -ANP levels, whereas HFJV was associated with significantly increased plasma α-ANP levels (from 60.0 ± 5.7 pg·mL -1 before anesthesia to 112.0 ± 11.6 pg·mL -1 after ventilation, P < 0.01). The urine output of the HFJV patients was significantly greater than that of the IPPV patients (P < 0.05).C Co on nc cl lu us si io on n: : These preliminary results suggest that HFJV is associated with a significant increase in plasma ANP and in urine output in anesthetized patients. TRIAL natriuretic peptide (ANP) is a cardiac hormone that has potent diuretic, natriuretic and vasorelaxant activities, and plays a role in regulating blood pressure and fluid homeostasis. 1 Recent studies have suggested that a decrease in the plasma ANP concentration contributes to the renal effects of controlled mechanical ventilation (CMV) with positive end-expiratory pressure (PEEP). [2][3][4] On the other hand, the authors have observed that polyuria has often been observed during high frequency jet ventilation (HFJV). However, little is known about the effects of HFJV on the plasma concentration of ANP and renal function. This study was designed to investigate the changes in the plasma ANP concentration during HFJV in comparison to IPPV in a clinical setting. Objectif : Déterminer si la ventilation en jet à haute fréquence (VJHF) influence la sécrétion de peptides natriurétiques auriculaires-α (PNA-α). Méthode

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Atrial Natriuretic Factor: A Hormone Produced by the Heart

Cited by 950 publications

References 54 publications

Circadian renal rhythms influenced by implanted encapsulated hANP-producing cells in Goldblatt hypertensive rats

Circadian renal rhythms influenced by implanted encapsulated hANP-producing cells in Goldblatt hypertensive rats

Atrial natriuretic peptide (ANP) in rat gastrointestinal tract

High frequency jet ventilation is associated with increased levels of plasma α-atrial natriuretic peptide — a preliminary study

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