Atrial Natriuretic Factor During the Perinatal Period: Equal Depletion in Both Atria'

Dolan, Lawrence M.; Young, Cheryl; Dobrozsi, D J

doi:10.1203/00006450-198904000-00005

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…This suggests diminishing basal (nonstimulated) ir-ANF release in the first few days after birth which correlates well with the observations of Dolan et al [1].…”

Section: Ir-anf Releasesupporting

confidence: 80%

“…This is consistent with diminishing ventricular ANF produc tion with progressive maturation, as has been previously observed in rats [20,21] and hu mans [22], However, the inability of this study to discriminate between ventricular and atrial ANF release to the perfusate prevents drawing such a conclusion with certainty. Alternatively, these data might represent readjustment in the balance of atrial ANF production and secretion, as suggested by the observation of Dolan et al [ 1], They reported biphasic change in ANF content of rat atria during the First 2 weeks after birth; ANF con tent declined during the first two days then increased to an apparent maximum by 15 days postpartum. Although comparison be tween rats and pigs carries some risk, our data suggest that decreasing basal (nonstimulated) ANF release during the First few days postpar tum could represent a resetting of a steadystate between ANF synthesis/storage and re lease.…”

Section: Ir-anf Releasementioning

confidence: 93%

“…Certain of these studies have demonstrated that steady-state production and storage of ANF are altered as a function of ontogeny [ 1 ] and can be affected by chronic pathophysiological states [2,3], Other studies interactions between ANF and insulin under normal and pathophysiological conditions. Efforts to explore the influence of ANF on insulin release have yielded conflicting re sults.…”

Section: Introductionmentioning

confidence: 99%

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Insulin Reduces Basal Release of Atrial Natriuretic Factor by Isolated, Perfused Neonatal Pig Hearts

Sicard

Feit²,

Werner³

1993

Neonatology

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Plasma atrial natriuretic factor (ANF) levels are markedly altered in diabetic rodents suggesting that insulin might be a modulator of ANF release. Effects of insulin (25 mU/ml) on basal (nonstimulated) immunoreactive (ir)-ANF release by isolated neonatal pig hearts paced at 150 beats/min and perfused with no change in atrial stretch were examined. Release of ir-ANF decreased with age from 1-3 days postpartum (146.0 ± 38.4 to 62.2 ± 20.5 fmol/g/min). Insulin stimulated myocardial glucose utilization and lactate production approximately 2-fold, but uniformly decreased ir-ANF release by approximately 25%, regardless of age. Correlations between ir-ANF release and myocardial metabolism suggest independent influences of insulin on these two events. In addition, it appears that this model might be reasonably exploited to investigate episodic ANF release and its regulation during ontogeny and in a variety of physiological states.

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“…This suggests diminishing basal (nonstimulated) ir-ANF release in the first few days after birth which correlates well with the observations of Dolan et al [1].…”

Section: Ir-anf Releasesupporting

confidence: 80%

Section: Ir-anf Releasementioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Insulin Reduces Basal Release of Atrial Natriuretic Factor by Isolated, Perfused Neonatal Pig Hearts

Sicard

Feit²,

Werner³

1993

Neonatology

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“…Dolan et al (26) reported significantly higher atrial ANP content in 15-d-old preweaned rat pups compared with adult rats. Inscho et al (27) also found a greater atrial ANP content in 15-d-old preweaned rats than in postweaned or adult rats (when ANP content was factored for protein content).…”

Section: Resultsmentioning

confidence: 99%

Dietary Sodium Modulates Neonatal but Not Adult Cardiac Atrial Natriuretic Peptide in Rats

et al. 1995

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After an initial postnatal diuresis, neonates are in positive sodium balance. Because atrial natriuretic peptide (ANP) contributes to sodium homeostasis, this study was designed to evaluate the maturational effects of increased dietary sodium intake on cardiac ANP production. Preweaned Sprague-Dawley rat pups were artificially reared by feeding them either a normalsodium or high-sodium diet for 7 d and were compared with maternally reared rat pups. Adult rats were divided into three groups: the first group was given ad libitum rat food and 1% sodium chloride to drink, the second group was pair-fed with this group but given tap water to drink, and the third group was fed ad libitum rat food and water for 10 d. Atrial and ventricular pro-ANP and ANP contents and plasma ANP concentrations were measured by RIA. Steady state atrial and ventricular ANP mRNA expression was determined by Northern and dot-blot analysis. There was a Zfold increase in atrial pro-ANP and ANP content and a 50% decrease in plasma ANP concentration in preweaned rat pups fed a high-salt diet. In contrast, atrial pro-ANP and ANP content and plasma ANP concentration were not affected by increased sodium intake in adult rats. Atrial and ventricular ANP mRNA levels and ventricular pro-ANP and ANP contents were not altered by dietary sodium at either age. We conclude thal chronic increase in sodium intake in the preweaning period results in increased storage of atrial pro-ANP. The decrease in plasma ANP concentration in these preweaned rats may be due to reduced basal secretion or enhanced degradation of the peptide. (Pediutr Res 37: 310-315, 1995) Abbreviations AH, adult high-sotlium diet AL, adult ad libitum diet AN, adult normal-sodium diet ANF, atrial natriuretic factor ANP, atrial natriuretic peptide GAPDH, glyceraltlehyde 3-phosphate dehydrogenase PWH, preweaned high-sodium diet PWM, preweaned maternally reared PWN, preweaned normal-sodium diet C-receptor, clearance receptor ANP, secreted primarily from atrial myocytes, exhibits natriuretic, diuretic, and vasorelaxant properties. Since 1981, when ANP was first described by de Bold et al. (I), the production, secretion, and actions of the peptide have been further elucidated. Although atrial stretch is generally recognized as the major stimulus for ANP release, recent studies suggest an important role for sodium ingestion in ANP regulation (2-4).In term and preterm infants, there is an initial diuresis and natriuresis that occur in conjunction with an increase in plasma

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Altered regulation of natriuretic peptides in the rat heart by prenatal exposure to morphine

Ernest

Jankowski

Mukaddam‐Daher

et al. 1998

The Journal of Physiology

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Both endogenous and exogenous opioids modulate blood pressure and cardiac function by stimulating cardiac synthesis of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP). Since morphine crosses the placental barrier, it could alter the ANF‐BNP system in the fetal heart. The aim of this study was to characterize cardiac natriuretic peptides in normal rat development and in rats prenatally exposed to morphine. Female rats received either saline or morphine (10 or 20 mg kg−1 day−1) via osmotic minipumps during gestation. The effects of this treatment were investigated in offspring at 1, 4 and 22 days of age. During maturation, atrial ANF and ANF mRNA increased by 3‐fold from birth to 3 weeks of age, but BNP and BNP mRNA tended to decrease. In the ventricles, both ANF and BNP content decreased at 3 weeks after birth, from 25.11 ± 3.6 to 0.81 ± 0.1 ng (P < 0.001), and from 3.36 ± 0.33 to 0.19 ± 0.01 ng (P < 0.001), respectively. However, whereas ventricular ANF mRNA decreased, BNP mRNA levels did not change during maturation. Prenatal exposure to morphine significantly increased ANF content in the left atria of 22‐day‐old rats, and in the right atria of 1‐, 4‐ and 22‐day‐old rats compared with age‐matched saline controls. In contrast, prenatal exposure to 20 mg kg−1 day−1 morphine significantly inhibited BNP and BNP mRNA in the ventricles at all ages studied. These observations suggest that alterations in mRNA synthesis or stability and/or post‐translational processing of ANF and BNP occur in the heart during maturation, and that prenatal exposure to morphine alters cardiac production, and possibly release, of both peptides.

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Atrial Natriuretic Factor During the Perinatal Period: Equal Depletion in Both Atria'

Cited by 5 publications

References 10 publications

Insulin Reduces Basal Release of Atrial Natriuretic Factor by Isolated, Perfused Neonatal Pig Hearts

Insulin Reduces Basal Release of Atrial Natriuretic Factor by Isolated, Perfused Neonatal Pig Hearts

Dietary Sodium Modulates Neonatal but Not Adult Cardiac Atrial Natriuretic Peptide in Rats

Altered regulation of natriuretic peptides in the rat heart by prenatal exposure to morphine

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