Atrial natriuretic factor-like peptide and its prohormone within single cell organisms

Vesely, David L.; Giordano, Amy T.

doi:10.1016/0196-9781(92)90160-5

Cited by 22 publications

(5 citation statements)

References 16 publications

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“…ANP is an almost ubiquitous hormone which has been detected in mammals, many reptiles, some single-cell organisms [125] and in several chlorophyll-containing plants, where it enhances solute flow [126]. NPs, and ANP in particular, appear to have a regulatory and integrating role in organo-and embryogenesis [36], i.e.…”

Section: Physiological Aspects In Health (Anp)mentioning

confidence: 99%

Modulation of the natriuretic peptide system in heart failure: from bench to bedside?

2003

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Since the discovery of atrial natriuretic peptide, the unravelling of the natriuretic peptide system has been a story of scientific success. However, bridging the gap between bench and bedside has proved difficult, and as yet has not provided any major clinical progress. In this review we will first give a detailed outline of the key elements constituting the natriuretic peptide system. Secondly, we will briefly explain the underlying rationale, basic concepts and evidence behind currently pursued strategies to potentiate the natriuretic peptide system. Thirdly, we will highlight some of the problems that have so far hindered successful translation of these theoretically viable treatment options into tangible clinical progress.

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Section: Physiological Aspects In Health (Anp)mentioning

confidence: 99%

Modulation of the natriuretic peptide system in heart failure: from bench to bedside?

2003

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“…Universally distributed (Table 2), NP are present in single-cell organisms (Vesely and Giordano, 1992), plants (Vesely and Giordano, 1991;Yang et al, 1999;Billington et al, 1997;Pharmawati et al, 1998) and invertebrates (Brownlee et al, 1993;Kim et al, 1994), including mollusks (Reinecke et al, 1989;Poulos et al, 1995). Their ubiquitous expression, conserved functions and high sequence homology indicate a long evolutionary history.…”

Section: Np-npr System: Molecular and Evolutionary Strategiesmentioning

confidence: 99%

Catecholamines, cardiac natriuretic peptides and chromogranin A: evolution and physiopathology of a ‘whip-brake’ system of the endocrine heart

Tota

Cerra

Gattuso

2010

Journal of Experimental Biology

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Summary In the past 50 years, extensive evidence has shown the ability of vertebrate cardiac non-neuronal cells to synthesize and release catecholamines (CA). This formed the mindset behind the search for the intrinsic endocrine heart properties, culminating in 1981 with the discovery of the natriuretic peptides (NP). CA and NP, co-existing in the endocrine secretion granules and acting as major cardiovascular regulators in health and disease, have become of great biomedical relevance for their potent diagnostic and therapeutic use. The concept of the endocrine heart was later enriched by the identification of a growing number of cardiac hormonal substances involved in organ modulation under normal and stress-induced conditions. Recently, chromogranin A (CgA), a major constituent of the secretory granules, and its derived cardio-suppressive and antiadrenergic peptides, vasostatin-1 and catestatin, were shown as new players in this framework, functioning as cardiac counter-regulators in ‘zero steady-state error’ homeostasis, particularly under intense excitatory stimuli, e.g. CA-induced myocardial stress. Here, we present evidence for the hypothesis that is gaining support, particularly among human cardiologists. The actions of CA, NP and CgA, we argue, may be viewed as a hallmark of the cardiac capacity to organize ‘whip-brake’ connection-integration processes in spatio-temporal networks. The involvement of the nitric oxide synthase (NOS)/nitric oxide (NO) system in this configuration is discussed. The use of fish and amphibian paradigms will illustrate the ways that incipient endocrine-humoral agents have evolved as components of cardiac molecular loops and important intermediates during evolutionary transitions, or in a distinct phylogenetic lineage, or under stress challenges. This may help to grasp the old evolutionary roots of these intracardiac endocrine/paracrine networks and how they have evolved from relatively less complicated designs. The latter can also be used as an intellectual tool to disentangle the experimental complexity of the mammalian and human endocrine hearts, suggesting future investigational avenues.

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“…Tetrahymena pyriformis, Neurospora crassa, and Aspergillus fumigatus contain (produce) substances, similar to mammalian insulins [5]. T. pyriformis also synthesizes neurotransmitters [17] and paramecium synthesizes atrial natriuretic peptide [18,19]. In addition, T. pyriformis synthesizes steroid hormones, as dehydroepiandrosterone (DHEA), DHEA sulfate, testosterone, and estradiol [20,21].…”

Section: Facts On Hormones In Unicellularsmentioning

confidence: 99%

Provocation of life functions at a unicellular eukaryote level by extremely low doses of mammalian hormones: Evidences of hormesis

Csaba

2019

AMicr

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Hormones, characteristic to higher ranked animals, are synthesized, stored, and secreted by unicellular eukaryote animals. The unicells also have receptors for recognizing these materials and transmit the message into the cells for provoking response. The hormones are effective in very low concentrations (down to 10–21 M) and opposite effects of lower and higher concentrations can be observed. However, sometimes linear concentration effects can be found, which means that hormesis exists, nevertheless uncertain, as it is in the phase of formation (evolutionary experimentation). Hormesis, by transformation (fixation) of cytoplasmic receptor-like membrane components to receptors in the presence of the given hormone, likely helps the development of unicellular endocrine character and by this the evolution of endocrine system. The effect by extremely low concentrations of hormones had been forced by the watery way of unicellular life, which could establish the physiological concentrations of hormones in the blood of higher ranked animals. This means that hormetic low doses are the normal, effective concentrations and the high concentrations are artificial, consequently could be dangerous.

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Atrial natriuretic factor-like peptide and its prohormone within single cell organisms

Cited by 22 publications

References 16 publications

Modulation of the natriuretic peptide system in heart failure: from bench to bedside?

Modulation of the natriuretic peptide system in heart failure: from bench to bedside?

Catecholamines, cardiac natriuretic peptides and chromogranin A: evolution and physiopathology of a ‘whip-brake’ system of the endocrine heart

Provocation of life functions at a unicellular eukaryote level by extremely low doses of mammalian hormones: Evidences of hormesis

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