Atrial natriuretic peptide and N‐terminal atrial natriuretic peptide in plasma reflect right ventricular volumes following coronary artery surgery

Honkonen, Eva-Liisa; Kaukinen, L.; Pehkonen, Erkki; Kaukinen, S.

doi:10.1111/j.1399-6576.1997.tb04767.x

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Several works have proposed that elevated plasma concentrations of NPs following cardiac surgery reflect heart function 15,26,27 . Morimoto et al 27 showed that the peak plasma BNP level 24 h after surgery has a relationship with CI and with cross‐clamp time.…”

Section: Discussionmentioning

confidence: 99%

Hyper osmolality does not modulate natriuretic peptide concentration in patients after coronary artery surgery

Honkonen

Järvelä

Huhtala

et al. 2009

Acta Anaesthesiol Scand

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Section: Discussionmentioning

confidence: 99%

Hyper osmolality does not modulate natriuretic peptide concentration in patients after coronary artery surgery

Honkonen

Järvelä

Huhtala

et al. 2009

Acta Anaesthesiol Scand

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“…Eine Betrachtung der Plasma-ANP-Bestimmung unter dem Gesichtspunkt der Möglichkeit zur Abschätzung einer kardialen Dysfunktion nach Bypasschirurgie erscheint naheliegend (7,8,24).…”

Section: Atrial Natriuretic Peptide (Anp)-levels Reveal Mild Postoperunclassified

Das atriale natriuretische Peptid als Indikator einer milden postoperativen kardialen Dysfunktion nach unkomplizierter Bypasschirurgie

Langenbach¹,

Korbmacher

Schulte

et al. 2000

Z Kardiol

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Plasma levels of ANP (pg/ml; radioimmunoassay) as a parameter for postischemic dysfunction and levels of Troponin T (TnT) (ng/ml; ELISA test) as a parameter for postischemic cellular damage were determined in 15 patients with coronary artery disease (CAD) (mean age: 58 +/- 6.1 years; 13 m, 2 w; with no history of myocardial infarction and no signs for congestive heart failure) prior to, during and after extracorporal circulation (ECC). Under standardized conditions during the ECC basic parameters concerning the cardial hemodynamic (heart rate (HR); systolic (RRsys, mmHg), diastolic pressure (RR dia, mmHg) central venous pressure (CVP, mmHg); left atrial pressure (LAP, mmHg); left ventricular enddiastolic pressure (LVEDP, mmHg)) and ECG monitoring blood samples were performed: 1) prior to operation (op); 2) prior to CPB; 3) 1 h CPB; 4) 5 min after CPB; 5) 1 h after CPB; 6) 6 h postoperative (postop); 7) 24 h postop; 8) 48 h postop; 9) 10 days postop. Also the left atrial diameter (LAD, mm) and the left ventricular enddiastolic diameter at Q (LVEDD, mm) pre- and postop were documented with m-mode echocardiography (Echo) and ejection fraction (EF, %) was calculated. The bypass operations were performed with intermittent aortic cross-clamping with open venae cavae (CVP: 0-5 mmHg) and moderate hypothermia. For the determination of ANP levels and TnT levels in arterial and venous blood, a double-antibody (AB) radioimmunoassay and an ELISA test were used. Concerning the patients with CAD there was a maximal increase of ANP from preoperative 90 +/- 10 (M +/- SEM) pg/ml (p < 0.05) up to intraoperative 380 +/- 38 pg/ml. Ten days postop, the ANP level was with 262 +/- 33 pg/ml still increased threefold in comparison to the preoperative level. TnT showed an increase from preoperative 0.02 +/- 0.01 ng/ml up to intraoperative 3.44 +/- 0.47 ng/ml. Ten days postop the TnT concentration was at the preoperative level with 0.13 +/- 0.11 ng/ml. Five minutes after bypass up to 48 h postop, ANP and TnT levels were correlated (p < 0.05, r = 3.4). There was an increase of the LAD from preoperative 42.2 +/- 1.1 mm up to 46.8 +/- 1.2 mm (p < 0.05) 10 days postop as determined by m-mode echo. LVEDD and EF changed from preoperative 51.1 +/- 0.9 mm and 73 +/- 2% to 54.5 +/- 1.2 mm and 65 +/- 4% 10 days postop. The significant increase of TnT (172-fold) indicates the cellular, myocardial injury, caused by the operation without signs in ECG recordings and no signs of congestive heart failure. The significantly increased ANP level up to the 10th day postop indicate sa very sensitive prolonged, postischemic dysfunction, which is not compensated 10 days postop.

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Natriuretic peptides stimulate cyclic guanosine monophosphate production in human saphenous vein and internal mammary artery

Bonatti

Dichtl

Lercher

et al. 2000

European Journal of Cardio-Thoracic Surgery

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The following median stimulated intracellular cyclic guanosine monophosphate concentrations were measured in the internal mammary artery and saphenous vein: 35358 and 8672 fmol/cm(2) (P<0.001) after atrial natriuretic peptide, 45632 and 7830 fmol/cm(2) (P=0.003) after brain natriuretic peptide, 10144 and 13216 fmol/cm(2) (P=NS for intergraft comparison) after C-type natriuretic peptide, and 20949 and 6690 fmol/cm(2) (P=0.001) after urodilatin. Stimulation with atrial natriuretic peptide, brain natriuretic peptide and urodilation also led to a significant increase of extracellular cyclic guanosine monophosphate release by the internal mammary artery. CONCLUSIONS We conclude that brain natriuretic peptide and urodilatin exhibit a similarly effective cyclic guanosine monophosphate-stimulating potential on the internal mammary artery as atrial natriuretic peptide. In contrast, C-type natriuretic peptide shows comparable effects on the internal mammary artery and saphenous vein.

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Atrial natriuretic peptide and N‐terminal atrial natriuretic peptide in plasma reflect right ventricular volumes following coronary artery surgery

Abstract: The relationships found between N-ANP and RV volume indexes and RV ejection fraction suggest ventricular expression of ANP: ANP release may be stimulated by RV distension, the more so the poorer the RV function.

Cited by 4 publications

References 26 publications

Hyper osmolality does not modulate natriuretic peptide concentration in patients after coronary artery surgery

Hyper osmolality does not modulate natriuretic peptide concentration in patients after coronary artery surgery

Das atriale natriuretische Peptid als Indikator einer milden postoperativen kardialen Dysfunktion nach unkomplizierter Bypasschirurgie

Natriuretic peptides stimulate cyclic guanosine monophosphate production in human saphenous vein and internal mammary artery

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