Atrial natriuretic peptide (ANP)-granules in the guinea pig atrial and auricular cardiocytes: an immunocytochemical and ultrastructural morphometric comparative study

Gama, Eliane Florêncio; Carvalho, Cláudio Antonio Ferraz de; Liberti, Édson Aparecido; Souza, Romeu Rodrigues de

doi:10.1016/j.aanat.2006.11.006

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…Atrial natriuretic peptide is synthesized in the myocytes of the atria and appendages, stored in granules of diverse number and size, and secreted in response to an increase in LA stretch ( Figure ) . Angiotensin, endothelin and the sympathetic nervous system also increase ANP secretion.…”

Section: Global Left Atrial Failure In Heart Failurementioning

confidence: 99%

Global left atrial failure in heart failure

Triposkiadis

Pieske

Butler

et al. 2016

European J of Heart Fail

127

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The left atrium plays an important role in the maintenance of cardiovascular and neurohumoral homeostasis in heart failure. However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, LA mechanical failure is accompanied by LA endocrine failure [deficient atrial natriuretic peptide (ANP) processing-synthesis/development of ANP resistance) and LA regulatory failure (dominance of sympathetic nervous system excitatory mechanisms, excessive vasopressin release) contributing to neurohumoral overactivity, vasoconstriction, and volume overload (global LA failure). The purpose of the present review is to describe the characteristics and emphasize the clinical significance of global LA failure in patients with heart failure.

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Section: Global Left Atrial Failure In Heart Failurementioning

confidence: 99%

Global left atrial failure in heart failure

Triposkiadis

Pieske

Butler

et al. 2016

European J of Heart Fail

127

View full text Add to dashboard Cite

show abstract

“…From 1983 to 1984 many researchers studied the biochemical composition of this factor. As a result, it was established that ANF has a protein nature, thus, it was called atrial natriuretic peptide (ANP) (Gama et al, 2007;Clerico et al, 2011). Later, scientists found that ANP is a hormone, which according to its diuretic and vasodilatation effects is an antagonist of the renin-angiotensinaldosterone system (Casserly et al, 2010;Kuhn, 2012).…”

Section: Fig 3 Representative Image Of Secretory Atrial Cardiomyocymentioning

confidence: 99%

Morphological features of atrial myocardium embryonic development and its changes caused by hypoxia effect

Shevchenko

2019

Regul. Mech. Biosyst.

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Mortality and morbidity during the prenatal period of development remain a real problem at the present time. The Scientific Committee EURO-PERISTAT has revealed that mortality of fetuses associated with congenital abnormalities is on average 15–20% across Europe. Hypoxia is one of the top causes of death of fetuses. Since the heart begins to function before birth, influence of teratogenic factors leads to formation of anomalies of its development. Congenital heart defects are the most common of these and occur with a frequency of 24%. Abnormalities associated with the atrium occur with frequency of 6.4 per 10,000 cases. Investigation of structural changes of the atrial myocardium is a key for understanding of pathogenic mechanisms of cardiovascular diseases that are caused by influence of hypoxia. Nowadays, a great deal of research is being dedicated to normal cardiogenesis and much less work is focused on abnormal heart development. There are numerous teratogenic factors such as alcohol, retinoic acid, hyperthermia, hypoxia that are most common causes of heart diseases. The attention of researchers has been predominantly focused on study of changes of the ventricular myocardium under the effect of hypoxia. It is known that the atrium is different from the ventricles by derivation, development and structure. Therefore, the effects of pathological factors on the atrial myocardium will be different as complared to their effect on the ventricles. Also, almost all research has focused on study of consequences of hypoxia at the late stages of cardiogenesis. However, the greatest number of abnormalities is associated with the early embryonic period, as structures that continue development are more sensitive to the effects of harmful factors. Thus, comparative analysis of scientific research devoted to morphological study of atrial myocardium transformations on the cellular and ultrastructural levels under the influence of hypoxia during the stages of cardiogenesis is an important task.

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“…Ten electron micrographs per animal obtained by systematic random sampling of quadrants examined with final magnification of x15, 000 were used to obtain: the number of granules per 96 μm 2 , the area of granules (μm 2 ) and the relative volume (%) of endoplasmic reticulum, mitochondria and Golgi complex [10][11][12][13] (Figure 1). The number of granules present in each field was determined and its area measured using an image analysis program (Axio Vision, Zeiss).…”

Section: Determination Of the Number And Sizes Of Np Granules And Thementioning

confidence: 99%

Effects of Aerobic Training on the Cardiomyocytes of the Right Atrium of Mice

Oliveira

Maifrino

Pithon‐Curi

et al. 2016

Rev Bras Med Esporte

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Introduction: Polypeptide hormones (natriuretic peptides, NPs) are secreted by the cardiac atria and play an important role in the regulation of blood pressure. Objective: To evaluate the effects of aerobic training on the secretory apparatus of NPs in cardiomyocytes of the right atrium. Methods: Nine-month-old mice were divided in two groups (n=10): control group (CG) and trained group (TG). The training protocol was performed on a motor treadmill for 8 weeks. Systolic blood pressure was measured at the beginning of the experiment (9 months of age) and at moment of the sacrifice (11 months of age). Electron micrographs were used to quantify the following variables: the quantitative density and area of NP granules, the relative volumes of the mitochondria, endoplasmic reticulum, and Golgi complex and the relative volume of euchromatin in the nucleus and the number of pores per 10 µm of the nuclear membrane. The results were compared by Student's t test (p< 0.05). Results: The cardiomyocytes obtained from TG mice showed increased density and sectional area of secretory granules of NP, higher relative volume of endoplasmic reticulum, mitochondria, and Golgi complex compared with the CG mice. Furthermore, the quantitative density of nuclear pores and the relative volume of euchromatin in the nucleus were significantly higher compared with the CG mice. Conclusion: Aerobic training caused hypertrophy of the secretory apparatus in the cardiomyocytes of right atrium, which could explain the intense synthesis of natriuretic peptides in trained mice with respect to the untrained mice.

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Atrial natriuretic peptide (ANP)-granules in the guinea pig atrial and auricular cardiocytes: an immunocytochemical and ultrastructural morphometric comparative study

Cited by 6 publications

References 30 publications

Global left atrial failure in heart failure

Global left atrial failure in heart failure

Morphological features of atrial myocardium embryonic development and its changes caused by hypoxia effect

Effects of Aerobic Training on the Cardiomyocytes of the Right Atrium of Mice

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