2017
DOI: 10.1016/j.carbpol.2016.11.049
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Atrial natriuretic peptide-conjugated chitosan-hydrazone-mPEG copolymer nanoparticles as pH-responsive carriers for intracellular delivery of prednisone

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Cited by 24 publications
(5 citation statements)
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“…Homogeneous dispersion of the particles suspension is indicated by PDI index, with values ranging from 0 to 1; homogeneous dispersion is revealed at values close to zero (Antoniraj, Kumar, Kumari, Natesan, & Kandasamy, 2017). As shown in Table 1, the PDIs were 0.409-0.873, which implied that the size was controlled with a narrow dispersity (Lazer et al, 2018).…”
Section: Size Distribution and ζ-Potential Determinationmentioning
confidence: 97%
“…Homogeneous dispersion of the particles suspension is indicated by PDI index, with values ranging from 0 to 1; homogeneous dispersion is revealed at values close to zero (Antoniraj, Kumar, Kumari, Natesan, & Kandasamy, 2017). As shown in Table 1, the PDIs were 0.409-0.873, which implied that the size was controlled with a narrow dispersity (Lazer et al, 2018).…”
Section: Size Distribution and ζ-Potential Determinationmentioning
confidence: 97%
“…The best tildipirosin composite nanogels in this investigation had mean particle sizes of 229.4 ± 1.5 nm (Figure C), a PDI of 0.26 ± 0.04, and a ZP of −33.2 ± 2.2 mV (Figure D). Particle size is one of the most important determinants for cellular absorption and intracellular particle trafficking, whereas small particles are more efficient than micron-sized particles in the delivery of drugs to the infected loci. , The PDI, which has a value between zero and one and measures particle homogeneity, is employed as an index to measure this property . To maintain a continuous and manageable medication release rate, a minimum PDI of 1 must be achieved.…”
Section: Resultsmentioning
confidence: 99%
“…18 Furthermore, the copolymer nanoparticles enable to be as a pH-responsive carrier and targeted drug delivery system. 19 For example, Liu synthesized a amphiphilic star copolymer, comprising a hydrophobic poly(methyl methacrylate) (PMMA) block and a hydrophilic triarm poly(N-isopropylacrylamide-co-N,N-dimethylaminoethyl methacrylate) (NI-PAAm-co-DMAEMA) block, that underwent self-assembly to the micellar nanoparticles with a core−shell structure for thermo and pH dual-responsive drug release, originating from the thermo-sensitivity of poly(NIPAAM) and the pHsensitivity of poly(DMAEMA). 20 Graphene has attracted considerable attention for the past few years as a new class of one-atom-thick 2D carbon nanomaterials, on account of its unique electronic structure and excellent physical, chemical, thermal, and mechanical performances.…”
Section: Introductionmentioning
confidence: 99%
“…For instance, Tao reported the magnetically core–shell Fe 3 O 4 @mesoporous polydopamine (Fe 3 O 4 @MPDA) nanospheres synthesized via a self-assembly approach, exhibiting good magnetic properties, a specific surface area of 17.27 m 2 g –1 and total pore volumes of 0.057 cm 3 g –1 , the average loading capacities of Fe 3 O 4 @MPDA toward DOX (doxorubicin hydrochloride) reached 295.2 mg g –1 , and the release amounts were about 41% within 60 h. The DOX-loaded Fe 3 O 4 @MPDA nanoparticles showed greater toxicity . Furthermore, the copolymer nanoparticles enable to be as a pH-responsive carrier and targeted drug delivery system . For example, Liu synthesized a amphiphilic star copolymer, comprising a hydrophobic poly­(methyl methacrylate) (PMMA) block and a hydrophilic triarm poly­( N -isopropylacrylamide- co - N , N -dimethylaminoethyl methacrylate) (NIPAAm- co -DMAEMA) block, that underwent self-assembly to the micellar nanoparticles with a core–shell structure for thermo and pH dual-responsive drug release, originating from the thermo-sensitivity of poly­(NIPAAM) and the pH-sensitivity of poly­(DMAEMA) …”
Section: Introductionmentioning
confidence: 99%