Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)

Song, Wei; Wang, Hao; Wu, Qingyu

doi:10.1016/j.gene.2015.06.029

Cited by 161 publications

(122 citation statements)

References 128 publications

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“…The research was performed in a hyperbaric chamber to eliminate the effect of physical activity and the temperature of the aquatic environment. In addition, biochemical analysis was performed on natriuretic peptides (BNP and ANP) involved in the regulation of haemodynamic circulation [16–19] and vasoconstriction (urotensin II) [20]; the level of the endogenic amino acid and the nitrogen oxide precursor (L-arginine) [21–23]; and measurement of parameters involved in cardiac remodeling (angiotensin II and angiotensin (1–7)) [24–28]. …”

Section: Introductionmentioning

confidence: 99%

Acute Biochemical, Cardiovascular, and Autonomic Response to Hyperbaric (4 atm) Exposure in Healthy Subjects

Kozakiewicz

Słomko

Buszko

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The aim of this study was to explore the effect of a hyperbaric environment alone on the cardiovascular system by ensuring elimination of factors that may mask the effect on hyperbaria. The research was performed in a hyperbaric chamber to eliminate the effect of physical activity and the temperature of the aquatic environment. Biochemical analysis and examination with the Task Force Monitor device were performed before and immediately after exposure. TFM was used for noninvasive examination of the cardiovascular system and the functional evaluation of the autonomic nervous system. Natriuretic peptides were measured as biochemical markers which were involved in the regulation of haemodynamic circulation vasoconstriction (urotensin II). L-arginine acted as a precursor of the level of the nitric oxide whereas angiotensin II and angiotensin (1–7) were involved in cardiac remodeling. The study group is comprised of 18 volunteers who were professional divers of similar age and experience. The results shown in our biochemical studies do not exceed reference ranges but a statistically significant increase indicates the hyperbaric environment is not without impact upon the human body. A decrease in HR, an increase in mBP, dBP, and TPR, and increase in parasympathetic heart nerves activity suggest an increase in heart afterload with a decrease in heart activity within almost one hour after hyperbaric exposure. Results confirm that exposure to a hyperbaric environment has significant impact on the cardiovascular system. This is confirmed both by changes in peptides associated with poorer cardiovascular outcomes, where a significant increase in the studied parameters was observed, and by noninvasive examination.

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Section: Introductionmentioning

confidence: 99%

Acute Biochemical, Cardiovascular, and Autonomic Response to Hyperbaric (4 atm) Exposure in Healthy Subjects

Kozakiewicz

Słomko

Buszko

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Atrial natriuretic peptide (ANP) is a cardiac hormone that promotes natriuresis and diuresis, thereby regulating salt-water balance [1, 2]. The ANP function is mediated by the natriuretic peptide receptor-A (NPR-A), also called guanylyl cyclase-A, which contains an intracellular guanylyl cyclase domain [3].…”

Section: Introductionmentioning

confidence: 99%

Localization of corin and atrial natriuretic peptide expression in human renal segments

et al. 2016

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Atrial natriuretic peptide (ANP)-mediated natriuretic response is a well-established cardiac endocrine function. Corin is a transmembrane protease that activates ANP in the heart. Corin expression has been detected in non-cardiac tissues including the kidney. Here we examined corin, pro-ANP/ANP and natriuretic peptide receptor-A (NPR-A) expression in human renal segments. By immunostaining and in situ hybridization, we found similar corin, pro-ANP/ANP and NPR-A protein and mRNA expression in human renal segments. The expression was most abundant in the proximal convoluted tubules and the medullary connecting ducts. In the proximal tubules, corin protein was present in the apical membrane region underneath the brush border where the ANP-degrading protease neprilysin was abundant. These results suggest that corin-mediated pro-ANP activation may occur in renal segments and that locally produced ANP may act in an autocrine manner to regulate sodium and water reabsorption in situ. Our results also point to the proximal convoluted tubules as a major site for local ANP action. Such a renal corin/ANP autocrine mechanism may differ from the cardiac corin/ANP endocrine mechanism in regulating sodium homeostasis under physiological and pathological conditions.

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“…The original observation of Kobayashi et al was that adenovirus-mediated knockdown of tescalcin resulted in hypertrophy of cultured neonatal ventricular myocytes (NRVMs) (Kobayashi et al, 2015). Here, the extent of cell enlargement was comparable to that caused by phenylephrine or IGF-1, and was accompanied by upregulation of atrial natriuretic peptide (ANP), a factor secreted by cardiac myocytes and one of the markers of pathologic heart hypertrophy and other conditions (Song et al, 2015). The magnitude of this effect demonstrated the importance of tescalcin in regulation of NRVM size and gene expression.…”

Section: Gsk3mentioning

confidence: 99%

Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation

Kolobynina

Solovyova

Levay

et al. 2016

Journal of Cell Science

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Tescalcin (TESC, also known as calcineurin-homologous protein 3, CHP3) is a 24-kDa EF-hand Ca2+-binding protein that has recently emerged as a regulator of cell differentiation and growth. The TESC gene has also been linked to human brain abnormalities, and high expression of tescalcin has been found in several cancers. The expression level of tescalcin changes dramatically during development and upon signal-induced cell differentiation. Recent studies have shown that tescalcin is not only subjected to up- or down-regulation, but also has an active role in pathways that drive cell growth and differentiation programs. At the molecular level, there is compelling experimental evidence showing that tescalcin can directly interact with and regulate the activities of the Na+/H+ exchanger NHE1, subunit 4 of the COP9 signalosome (CSN4) and protein kinase glycogen-synthase kinase 3 (GSK3). In hematopoetic precursor cells, tescalcin has been shown to couple activation of the extracellular signal-regulated kinase (ERK) cascade to the expression of transcription factors that control cell differentiation. The purpose of this Commentary is to summarize recent efforts that have served to characterize the biochemical, genetic and physiological attributes of tescalcin, and its unique role in the regulation of various cellular functions.

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Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)

Cited by 161 publications

References 128 publications

Acute Biochemical, Cardiovascular, and Autonomic Response to Hyperbaric (4 atm) Exposure in Healthy Subjects

Acute Biochemical, Cardiovascular, and Autonomic Response to Hyperbaric (4 atm) Exposure in Healthy Subjects

Localization of corin and atrial natriuretic peptide expression in human renal segments

Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation

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