Atrial Natriuretic Peptide Levels in Treated Congestive Heart Failure

Katoh, Yoh; Kurosawa, Toshiro; Takeda, Sadao; Kurokawa, Syuhei; Sakamotom, Hisato; Marumo, Fumiaki; Kikawada, Ryuichi; Singer, Donald H.; Shore, AngelaC.; Markandu, Nirmala D.; Buckley, M. G.; MacGregor, G. A.

doi:10.1016/s0140-6736(86)90955-4

Cited by 33 publications

(13 citation statements)

References 6 publications

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“…31 However, we consider that the present RSD values would be acceptable for on-site monitoring of natriuretic peptide for clinical diagnosis, because the peptide concentration in blood significantly increases in heart failure patients. 11,12 Recovery tests of spiked samples with ANP To explore the applications of the present method, we performed recovery tests for ANP spiked in human serum. The human serum was a 1:5 diluted sample that was filtered before the measurement.…”

Section: Anp Measurementmentioning

confidence: 99%

“…[4][5][6][7][8][9][10] The concentrations of ANP and BNP in our blood under normal conditions are extremely low (< 40 pg mL -1 (ppt)), but rise to by 10 -100 fold in patients with severe congestive heart failure. 11,12 To measure such low concentrations of peptides, recearchers have developed and commercialized highly-sensitive radioimmunoassays or enzyme immunoassays based on chemiluminescence or fluorescence. [13][14][15][16] However, simple and inexpensive bedside measurements in ambulances, hospitals, and homes are difficult to accomplish with these methods, because the aforementioned methods require expensive and massive apparatuses.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Enzymatic Recycling Electrodes for Measuring Aminophenol: Development of a Highly Sensitive Natriuretic Peptide Assay System

et al. 2008

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Several redox enzymes were examined for enzymatic/electrochemical-recycling systems in order to measure p-aminophenol (PAP) with high sensitivity. Glucose oxidase (GOD) and diaphorase (DI) worked well as catalysts for recycling electrode systems: these enzymes effectively reduced p-iminoquinone (PIQ), the electrochemically-oxidized form of PAP, and caused an enhancement in the electrochemical signals (anodic currents in the voltammogram and amperogram) by ~100 fold. The lower detection limits for PAP were estimated to be 50 nM with the GOD system and 2 nM with the DI system. We combined the enzymatic-recycling electrode using DI with an enzyme immunoassay system to measure atrial natriuretic peptide (ANP), an important marker peptide hormone involved in heart diseases. ANPs from serum samples at ppt-levels were determined appropriately using the present assay system.

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Section: Anp Measurementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of Enzymatic Recycling Electrodes for Measuring Aminophenol: Development of a Highly Sensitive Natriuretic Peptide Assay System

et al. 2008

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“…The plasma ANF concentration correlates with clinical measures of failure Tikkanen et al, 1985;Katoh et al, 1986) and with more direct measures of cardiac overload (Bates et al, 1986;Burnett et al, 1986;Dietz et al, 1986;Lang et al, 1986;Raine et al, 1986;Richards et al, 1986). There is a negative relationship with cardiac function (Schiffrin & Taillefer, 1986).…”

Section: Discussionmentioning

confidence: 99%

Effect of captopril on functional, physiological and biochemical outcome criteria in aged heart failure patients.

O'neill

Charlett

Dobbs

et al. 1992

Brit J Clinical Pharma

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1 Captopril was evaluated as an adjuvant to diuretic and digoxin therapy in heart failure in old age, using walking ability, minute ventilation and oxygen consumption and plasma atrial natriuretic factor (ANF) (6) years, and the increase on exercise, seen in the controls (P < 0.01), was absent. In the patients the resting plasma ANF concentration was significantly affected by treatment (P = 0.03), being less on both AP, 245 (9), and AA, 214 (9) than on PP, 264 (10) pmol 1-1 (P = 0.02 and 0.03, respectively).7 Baseline serum ACE activity was induced on active treatment. The change in ACE activity at 3 h post an active dose was significantly greater on AP than AA (P = 0.005).The increased sensitivity to inhibition during once daily administration was reflected in mean arterial pressure. The pre-dose standing pressure was less on AP than on PP (P < 0.05), and the change in postural fall (pre-dose minus 2 h post), was greater (P = 0.004), but AA and PP were similar in these respects. 8 A linear model, taking account of structure of the study, change in ACE activity and standing blood pressure, showed a significant effect of treatment on distance walked in the SWT (P = 0.04), enhanced the overall effect on resting ANF (P = 0.02), but failed to reveal any effect on the ventilation to oxygen consumption ratio. 9 Putative adverse effects caused withdrawal in 6/26 patients in the pre-trial period,

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“…Elevated levels have also been reported in a variety of other conditions including pregnancy (Cusson et al, 1985), syndrome of inappropriate secretion of antidiuretic hormone and water loading (Cogan et al, 1986) and Bartter's syndrome (Tunny & Gordon, 1986). Values as high as 100-300 pmol/l are not unusual in severe heart failure and may fall to lower levels after effective treatment (Katoh et al, 1986). Raised levels are also found in children with congenital heart disease as well as children with bronchopulmonary dysplasia , conditions known to be associated with high atrial pressure.…”

Section: P a T~~l~~~~u~ Statesmentioning

confidence: 99%