1990
DOI: 10.1111/j.1540-8159.1990.tb02142.x
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Atrial Natriuretic Peptide Levels Reflect Hemodynamic Changes Under Pacemaker Stimulation

Abstract: Pacemaker stimulation influences plasma levels of atrial natriuretic peptide (ANP). This study evaluated in individuals without impaired myocardial function whether a consecutive increase of pacing rates results in reduced alteration of plasma ANP levels mirroring a putative decrease of atrial contribution to cardiac output. In nine resting patients with DDD pacemakers, absolute and relative ANP plasma levels were determined under DDD (175 msec AV delay) and VVI pacing at a pacing rate of 72, 82, 92, and 113 b… Show more

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Cited by 9 publications
(2 citation statements)
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“…Furthermore, levels of ANF at rest and during stress have been used to evaluate the physiologic performance of various pacing modalities. [15][16][17][18][19][20] It is, therefore, surprising that the characteristics of the time course and the pattern by which ANF rises following the onset of ventricular pacing have not been fully established; additionally, the physiologic role of the hormone in this setting has remained unclear. This study was designed to characterize the acute rise of ANF following the onset of ventricular pacing and to establish at what point the levels stabilized, so that future studies could be planned accordingly.…”
mentioning
confidence: 99%
“…Furthermore, levels of ANF at rest and during stress have been used to evaluate the physiologic performance of various pacing modalities. [15][16][17][18][19][20] It is, therefore, surprising that the characteristics of the time course and the pattern by which ANF rises following the onset of ventricular pacing have not been fully established; additionally, the physiologic role of the hormone in this setting has remained unclear. This study was designed to characterize the acute rise of ANF following the onset of ventricular pacing and to establish at what point the levels stabilized, so that future studies could be planned accordingly.…”
mentioning
confidence: 99%
“…Christensen and coworkers [2] found that a substantial part of plasma ANP increase during pacing tachycardia is related to a rise in the A wave in the atrial pressure tracing and, accordingly, to systolic wall tension. An acute direct effect of pacemaker stimulation on ventricular ANP secretion was not observed [21]. However, chronic pacing seems to stimulate the expression of ANP in cultured ventricular myocardium cells.…”
Section: Discussionmentioning
confidence: 93%