Atrial Natriuretic Peptide Prohormone Gene Expression: Hormones and Diseases That Upregulate its Expression

Vesely, David L.

doi:10.1080/15216540212336

Cited by 79 publications

(105 citation statements)

References 37 publications

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“…Atrial natriuretic peptide (ANP), comprising the COOH-terminal amino acid residues 99 to 126 of the ANP prohormone, has been extensively studied for its functions in relation to blood pressure regulation (1)(2)(3)(4)(5)(6)(7)(8). Its receptor, natriuretic peptide receptor A (NPRA), is expressed on cells in many different tissues of various organ systems and signals through guanylyl cyclase.…”

Section: Introductionmentioning

confidence: 99%

Natriuretic Peptide Receptor A as a Novel Anticancer Target

Kong¹,

Wang

et al. 2008

Cancer Research

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The receptor for atrial natriuretic peptide (ANP), natriuretic peptide receptor A (NPRA), is expressed in cancer cells, and natriuretic peptides have been implicated in cancers. However, the direct role of NPRA signaling in tumorigenesis remains elusive. Here, we report that NPRA expression and signaling is important for tumor growth. NPRA-deficient mice showed significantly reduced antigen-induced pulmonary inflammation. NPRA deficiency also substantially protected C57BL/6 mice from lung, skin, and ovarian cancers. Furthermore, a nanoparticle-formulated interfering RNA for NPRA attenuated B16 melanoma tumors in mice. Ectopic expression of a plasmid encoding NP73-102, the NH 2 -terminal peptide of the ANP prohormone, which down-regulates NPRA expression, also suppressed lung metastasis of A549 cells in nude mice and tumorigenesis of Line 1 cells in immunocompetent BALB/c mice. The antitumor activity of NP73-102 was in part attributed to apoptosis of tumor cells. Western blot and immunohistochemistry staining indicated that the transcription factor, nuclear factor-KB, was inactivated, whereas the level of tumor suppressor retinoblastoma protein was upregulated in the lungs of NPRA-deficient mice. Furthermore, expression of vascular endothelial growth factor was downregulated in the lungs of NPRA-deficient mice compared with that in wild-type mice. These results suggest that NPRA is involved in tumor angiogenesis and represents a new target for cancer therapy. [Cancer Res 2008;68(1):249-56]

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Section: Introductionmentioning

confidence: 99%

Natriuretic Peptide Receptor A as a Novel Anticancer Target

Kong¹,

Wang

et al. 2008

Cancer Research

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“…Atrial natriuretic peptide (ANP), a member of the family of natriuretic peptides, regulates a variety of physiological parameters including diuresis and natriuresis, and reduces systemic blood pressure [1,2]. Mature ANP is cleaved from carboxylterminal amino acids of the prohormone of ANP.…”

Section: Introductionmentioning

confidence: 99%

“…Mature ANP is cleaved from carboxylterminal amino acids of the prohormone of ANP. The N-terminal portion of the prohormone is secreted in the same molar ratio as ANP [2][3][4]. Because of its longer half-life, the N-terminal portion of proANP, particularly the mid region of this molecule (MR-proANP) has been shown to be a more reliable analyte [4].…”

Section: Introductionmentioning

confidence: 99%

Circulating levels of pro‐atrial natriuretic peptide in lower respiratory tract infections

Müller

Süess

Schuetz

et al. 2006

Journal of Internal Medicine

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“…In the kidney, as opposed to all other tissues, differential processing of ANP pro hormone occurs, where instead of cleaving the prohormone between amino aids 98 and 99 to form ANP and kaliuretic peptide, it is cleaved between amino acids 95 and 96 (29,(34)(35)(36). This results in four amino acids from the C-terminal of kaliuretic peptide (i.e.…”

Section: Other Anticancer Peptidesmentioning

confidence: 99%

“…threonine-alanine-proline-arginine) being attached to the Nterminal of ANP, with the resulting peptide being called urodilatin (29,(34)(35)(36). It is important to note that the amino acids in urodilatin are identical to the four C-terminal amino acids of kaliuretic peptide and identical to all of the amino acids in ANP (29,(34)(35)(36). Urodilatin reduces the number of renal carcinoma cells by 66% at 100 μM, while ANP and kaliuretic peptide at the same concentration eliminate 70% and 74% of renal carcinoma cells in 24 hours (13).…”

Section: Other Anticancer Peptidesmentioning

confidence: 99%

Heart Peptide Hormones: Adjunct and Primary Treatments of Cancer

Vesely

2016

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Abstract. Four heart hormones, namely atrial natriuretic peptide (ANP), long-acting natriuretic peptide (LANP), these pathways and their crosstalk is inhibited by these peptide hormones. They enter the nucleus of cancer cells where they inhibit the proto-oncogenes c-FOS (by up to 82%) and c-JUN (by up to 61%). Conclusion: These multiple kinase inhibitors have both adjunct and primary anticancer effects.The amino acid sequences of atrial natriuretic peptide (ANP) and the ANP prohormone from which it is derived were determined in 1984 (1-8). ANP has anticancer effects both in vitro (9-20) and in vivo (21, 22). ANP eliminates 80% of human pancreatic carcinomas (21) and 43% of human small cell lung carcinomas growing in mice (22). Recently ANP has been used for 3 hours intravenously as an adjunct after 'curative' lung cancer surgery, which resulted in a 2-year relapse-free survival of 91% (77 patients) versus 75% (p=0.018) in 390 patients treated with surgery alone (23). When peer-matched patients (77 each) were analyzed by propensity score matching, the 2-year relapse-free survival was 91% for those treated with ANP versus 67% for those treated with surgery alone (p=0.0013) (23). This study would suggest that adding ANP after surgery as an adjunct may be helpful in preventing recurrence after surgery (23). The present review focuses on the mechanism of how ANP and other cardiac peptide hormones eliminate primary carcinomas in vivo and metastatic lesions (21, 22). ANPANP prohormone can produce four hormones, one of which is ANP. The ANP prohormone gene encoding the synthesis of the 126 amino acid ANP prohormone consists of three exons sequences, separated by two introns, which encode for a mature mRNA transcript approximately 900 bases long (3,(24)(25)(26)(27). Translation of the human ANP prohormone mRNA results 5693

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Atrial Natriuretic Peptide Prohormone Gene Expression: Hormones and Diseases That Upregulate its Expression

Abstract: SummaryAtrial natriuretic peptides consist of a family of peptide hormones that are synthesized by three separate genes and then stored as three different prohormones (i.

Cited by 79 publications

References 37 publications

Natriuretic Peptide Receptor A as a Novel Anticancer Target

Natriuretic Peptide Receptor A as a Novel Anticancer Target

Circulating levels of pro‐atrial natriuretic peptide in lower respiratory tract infections

Heart Peptide Hormones: Adjunct and Primary Treatments of Cancer

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