Atrial natriuretic peptide property on the ischemic myocardium inducing HSP72

Olivito, Silvio; Chello, Massimo; Covino, Elvio; Mastroroberto, Pasquale

doi:10.1177/0218492313484735

Cited by 1 publication

(1 citation statement)

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“…Considering miR-133b, its up-regulation in AD patients is in agreement with experimental studies in canine, rabbit, and ovine models of heart failure (Belevych et al, 2011; Olivito et al, 2014; Wong et al, 2017), a condition associated with atrial stretch and increased atrial pressure. As well the negative association of miR-133b with the presence of AF is consistent with previous studies, showing miR-133 down-regulation in canine AF (Shan et al, 2009; Li et al, 2012), and in atrial samples from AF patients with smoking versus non-smoking habits (Shan et al, 2009).…”

Section: Discussionsupporting

confidence: 84%

Upregulation of miR-133b and miR-328 in Patients With Atrial Dilatation: Implications for Stretch-Induced Atrial Fibrillation

et al. 2019

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Atrial stretch and dilatation are common features of many clinical conditions predisposing to atrial fibrillation (AF). MicroRNAs (miRs) are emerging as potential molecular determinants of AF, but their relationship with atrial dilatation (AD) is poorly understood. The present study was designed to assess the specific miR expression profiles associated with AD in human atrial tissue. The expressions of a preselected panel of miRs, previously described as playing a role in cardiac disease, were quantified by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in atrial tissue samples from 30 cardiac surgery patients, who were characterized by different grades of AD and arrhythmic profiles. Our results showed that AD per se was associated with significant up-regulation of miR-328-3p and miR-133b (p < 0.05) with respect to controls, with a fold-change of 1.53 and 1.74, respectively. In a multivariate model including AD and AF as independent variables, miR-328-3p expression was mainly associated with AD grade (p < 0.05), while miR-133b was related to both AD (p < 0.005) and AF (p < 0.05), the two factors exerting opposite modulation effects. The presence of AF was associated with significant (p < 0.05) up-regulation of the expression level of miR-1-3p, miR-21-5p, miR-29a-3p, miR-208b-3p, and miR-590-5p. These results showed the existence of specific alterations of miR expression associated with AD, which may pave the way to future experimental studies to test the involvement of post-transcriptional mechanisms in the stretch-induced formation of a pro-arrhythmic substrate.

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