The combination of constrictive pericarditis (CP) and atrial septal defect (ASD) is a rare medical condition. Surgical intervention is typically considered the superior treatment option for patients with this condition. In this report, we present a rare case where a patient presented both a large ASD and severe tuberculous CP. The role of anesthesia is crucial in surgical procedures involving this complex cardiac conditions. Factors such as hemodynamic stability, fluid management, and preservation of cardiac function must be carefully considered. The utilization of transesophageal echocardiography (TEE) proved highly advantageous in this case, as it guided the medical team through various phases of treatment. By closely monitoring cardiac function with TEE, changes and improvements be accurately evaluated over time. This case report discusses the anesthetic management issues of this complex disease.