Atrial Structure and Function and its Implications for Current and Emerging Treatments for Atrial Fibrillation

Prabhu, Sandeep; McLellan, A.; Walters, Tomos E.; Sharma, Meenal; Voskoboinik, A.

doi:10.1016/j.pcad.2015.08.004

Cited by 25 publications

(18 citation statements)

References 145 publications

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“…Remodelling of the left atrium reflects a spectrum of structural and electrical alterations in the atrial tissue leading to atrial dilation and impairment of normal atrial function . The remodelling develops in response to specific stressors, the most common being volume/pressure overload, such as in HF syndromes and tachycardia with high rates of cell depolarization .…”

Section: Global Left Atrial Failure In Heart Failurementioning

confidence: 99%

Global left atrial failure in heart failure

Triposkiadis

Pieske

Butler

et al. 2016

European J of Heart Fail

127

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The left atrium plays an important role in the maintenance of cardiovascular and neurohumoral homeostasis in heart failure. However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, LA mechanical failure is accompanied by LA endocrine failure [deficient atrial natriuretic peptide (ANP) processing-synthesis/development of ANP resistance) and LA regulatory failure (dominance of sympathetic nervous system excitatory mechanisms, excessive vasopressin release) contributing to neurohumoral overactivity, vasoconstriction, and volume overload (global LA failure). The purpose of the present review is to describe the characteristics and emphasize the clinical significance of global LA failure in patients with heart failure.

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Section: Global Left Atrial Failure In Heart Failurementioning

confidence: 99%

Global left atrial failure in heart failure

Triposkiadis

Pieske

Butler

et al. 2016

European J of Heart Fail

127

View full text Add to dashboard Cite

show abstract

“…Известно, что размер левого предсердия (ЛП) является предиктором развития СН, а увеличение ЛП и его дисфункция являются важными предикторами клинических исходов [11,12]. По данным мета-анализа 18 исследований, посвященных изучению ХСН, максимальный объем ЛП оказался независимым предиктором смерти или необходимости в трансплантации сердца в течение 41 месяца наблюдения у 337 больных ХСН и дилатационной кардиомиопатией [13].…”

Section: оригинальные статьи § введениеunclassified

The effect of angiotensin receptors and neprilysin inhibitors on myocardial remodeling in patients with chronic heart failure and atrial fibrillation

et al. 2019

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Aim. To evaluate the effect of angiotensin-neprilysin receptor inhibitors on myocardial remodeling in patients with chronic heart failure and atrial fibrillation. Materials and methods. We studied dynamics of the parameters of ultrasound structural and functional parameters of the left atrium and left ventricle of the heart was during 3-month therapy with sacubitryl-valsartan in a group of 15 patients with a combination of chronic heart failure due to dilated and paroxysmal paroxysmal forms of atrial fibrillation. Results. Showed a statistically significant positive effect of the use of angiotensin receptors and neprilysin inhibitors on the parameters of remodeling of the left atrium (according to transthoracic and transesophageal echocardiography), left ventricle, as well as levels of natriuretic peptides ANP and NT-pro-BNP. Conclusion. The use of ARNI may be promising in terms of treatment and prevention of AF in patients with heart failure.

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“…204,205,206 Because of this common site of initiation, complete electrical isolation of the pulmonary veins (PVI) is usually the primary endpoint in catheter ablation of AF. 49,204,205,207 During a PVI procedure, lesions are created encircling the antrum the pulmonary veins, which results in non-conducting scar, thereby electrically isolating the PV muscle sleeves and their triggers from the rest of the myocardium. 208 This is commonly performed either with delivery of radiofrequency energy via an ablation catheter delivering connecting circumferential lesions around the veins, or via cryo-injury with a cryoablation balloon-tipped catheter.…”

Section: Atrial Fibrillation Ablationmentioning

confidence: 99%

Current Evidence-Based Understanding of the Epidemiology, Prevention, and Treatment of Atrial Fibrillation

Rogers

Bernard

Madias

et al. 2018

Current Problems in Cardiology

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Atrial fibrillation (AF) is the most common atrial arrhythmia in adults worldwide. As medical advancements continue to contribute to an ever-increasing aging population, the burden of atrial fibrillation on the modern health care system continues to increase. Therapies are also evolving, for treatment of the arrhythmia itself, and stroke risk mitigation. Internists and cardiologists alike are, in most instances, the frontline contact for AF patients, and would benefit from remaining facile in their understanding of care options. To continue to deliver high-quality care to this expanding patient group, an updated, concise review for the clinician is prudent. This article provides a comprehensive summary of the current epidemiology and pathophysiology of AF, as well as contemporary procedural therapeutic options.

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Atrial Structure and Function and its Implications for Current and Emerging Treatments for Atrial Fibrillation

Cited by 25 publications

References 145 publications

Global left atrial failure in heart failure

Global left atrial failure in heart failure

The effect of angiotensin receptors and neprilysin inhibitors on myocardial remodeling in patients with chronic heart failure and atrial fibrillation

Current Evidence-Based Understanding of the Epidemiology, Prevention, and Treatment of Atrial Fibrillation

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