Atrial volumetric measurement has proven clinical implications. Advances in cardiac imaging, notably the precision enabled by multidetector computed tomography (MDCT),A trial volume enlargement is an important diagnostic and prognostic indicator for patients with coronary artery disease (CAD). In various diseases, an increase in left atrial (LA) size has been associated with poor outcomes.
1-5In patients with CAD, LA enlargement is a known risk factor for an unfavorable cardiovascular prognosis. 6 In addition, right atrial (RA) enlargement might indirectly contribute to this risk by affecting the systemic and coronary vasculature. Multidetector computed tomography (MDCT) enables 3-dimensional imaging of the heart and correlates well with results of echocardiography and magnetic resonance imaging (MRI).7 In this study, we used MDCT angiography to identify normal ranges of LA and RA volumes in men and women and to calculate the prevalence of atrial enlargement in individuals with CAD.
Patients and MethodsThe study protocol and method of consent were approved by our institutional review board. We reviewed our clinical database of patients who had been examined for evaluation of coronary artery disease with use of computed tomographic angiography (CTA) in our department from November 2007 through December 2010. A total of 1,400 records were reviewed; any patient with a historical diagnosis of valvular disorders, atrial fibrillation, or pulmonary hypertension was excluded from consideration. The remaining 686 participants (Table I) subsequently underwent examination by means of electrocardiographic (ECG)-gated CTA. We estimated the presence and extent of CAD, and cardiac systolic function.We then divided the study population into a control group (203 healthy subjects) and an obstructive-CAD group (483 patients) as diagnosed by CTA. Exclusionary