Atriopeptins. II. Synthesis of N-terminal fragments

Abstract

Peptides, corresponding to the N-terminal sequence in atriopeptins, were synthesized by classical methods of peptide chemistry in solution. The obtained peptides were characterized by various physicochemical methods. The scheme and methods of the synthesis are discussed.

Highly Diastereoselective Peptide Chain Extensions of Unprotected Amino Acids withN-(Z-α-Aminoacyl)benzotriazoles

“…Found: C, 60.13; H, 7.64; N, 9.94. (5S)-5-Benzyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic Acid (Z-Phe-Gly-Gly-OH, 4c) 35Colorless microcrystals (98%); mp 120-122°C (Lit 35. mp 122-125°C); [a] D 25 -21.4 (c = 1.4, DMF) {Lit.…”