Atriopeptins. III. Synthesis and biological activity studies of α-r-ANF, AP-II, AP-III and des-Ser5-Ser6-AP-II

Abstract

Starting from previously synthesized atriopeptin fragments, peptides α-r-ANF, AP-II, AP-III and des-Ser5-Ser6-AP-II were prepared using complex F. The acetamidomethyl protecting group on cysteine was removed simultaneously with the cyclization. Biological activity of atriopeptin was evaluated.