Objectives: Revalidation of Killip class in our local population is mandatory. We planned this study to increase cardiologist readiness to tackle the risks associated with increased mortality in each class post ST elevation myocardial infarction (STEMI). Objectives were to determine frequency of Killip class I, II, III, IV and in-hospital mortality in each Killip class in patients with left ventricle failure secondary to STEMI.Results: This cross-sectional Study was conducted in Department of Cardiology, Jinnah Hospital. Patients with STEMI were stratified using Killip Class and validation was performed by determining the within 15 days in-hospital mortality in each Killip class. Patients with chronic disease were excluded. The frequency (percentage) of patients with STEMI in each killip class from I to IV was 395 (81.4%), 46 (9.5%), 27(5.6%) and 17(3.5%) respectively while in-hospital mortality came out to be, 39 (9.8%), 4 (8.6%), 25 (92.5%), and 17(100%), in Killip class I, II, III and IV respectively. Presence of diabetes, history of smoking and BMI more than 30kg/m2 were significant contributor to mortality along with higher Killip class and age of presentation. It is concluded that Killip class is a valid tool for risk stratification for patients after STEMI.