“…As regards the procedural –modifiable- risk factors and depth of implantation, one study (n = 65; CoreValve only) reported a frame depth in the LVOT of 11.1 mm as an independent predictor of PPI with 81% sensitivity and 84.6% specificity [ 22 ]. Similarly, another study revealed that if the proximal end of the valve frame was positioned <6.7 mm from the lower edge of the noncoronary cusp, no prosthesis-related left bundle branch block would occur [ 23 ].…”