Atropa belladonna Expresses a microRNA (aba-miRNA-9497) Highly Homologous to Homo sapiens miRNA-378 (hsa-miRNA-378); both miRNAs target the 3′-Untranslated Region (3′-UTR) of the mRNA Encoding the Neurologically Relevant, Zinc-Finger Transcription Factor ZNF-691

Avşar, Bihter; Zhao, Yuhai; Li, Wenhong; Lukiw, Walter J.

doi:10.1007/s10571-019-00729-w

Cited by 23 publications

(15 citation statements)

References 53 publications

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“…In this study we included a homology analysis, identifying 7 wheat-derived miRNAs show homology with 9 human miRNAs, revealing a series of target genes in common, through our prediction. Although plant sequences do not show high homology with human sequences, results obtained by author [ 39 ], show that they can perform similar functional activities to endogenous sequences, in a cross-kingdom interaction [ 19 ]. Therefore, we consider this dataset provides a solid basis for future projects.…”

Section: Discussionmentioning

confidence: 99%

Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: A cross kingdom computational approach

Sánchez-Romo

Hernández-Vásquez

Pereyra-Alférez

et al. 2022

Non-coding RNA Research

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Section: Discussionmentioning

confidence: 99%

Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: A cross kingdom computational approach

Sánchez-Romo

Hernández-Vásquez

Pereyra-Alférez

et al. 2022

Non-coding RNA Research

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“…Aba miRNA 9497 derived from Atropa belladonna L , has a highly homologous sequence to miRNA-378 of Homo sapiens . Avsar et al (2020) have demonstrated for the first time that both aba miRNA 9497 and miRNA-378 could downregulate the mRNA expression of human CNS-enriched ZNF-691 by binding to 3′-UTR of this gene. The authors speculated that the neurotoxic actions of Atropa belladonna may partially results from the modulation role of ZNF-691 by aba-miRNA-9497.…”

Section: Anti-inflammationmentioning

confidence: 97%

A Timely Review of Cross-Kingdom Regulation of Plant-Derived MicroRNAs

Yang

et al. 2021

Front. Genet.

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MicroRNAs (miRNAs) belong to a class of non-coding RNAs that suppress gene expression by complementary oligonucleotide binding to the sites in target messenger RNAs. Numerous studies have demonstrated that miRNAs play crucial role in virtually all cellular processes of both plants and animals, such as cell growth, cell division, differentiation, proliferation and apoptosis. The study of rice MIR168a has demonstrated for the first time that exogenous plant MIR168a influences cholesterol transport in mice by inhibiting low-density lipoprotein receptor adapter protein 1 expression. Inspired by this finding, the cross-kingdom regulation of plant-derived miRNAs has drawn a lot of attention because of its capability to provide novel therapeutic agents in the treatment of miRNA deregulation-related diseases. Notably, unlike mRNA, some plant miRNAs are robust because of their 3′ end modification, high G, C content, and the protection by microvesicles, miRNAs protein cofactors or plant ingredients. The stability of these small molecules guarantees the reliability of plant miRNAs in clinical application. Although the function of endogenous miRNAs has been widely investigated, the cross-kingdom regulation of plant-derived miRNAs is still in its infancy. Herein, this review summarizes the current knowledge regarding the anti-virus, anti-tumor, anti-inflammatory, anti-apoptosis, immune modulation, and intestinal function regulation effects of plant-derived miRNAs in mammals. It is expected that exploring the versatile role of plant-derived miRNAs may lay the foundation for further study and application of these newly recognized, non-toxic, and inexpensive plant active ingredients.

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“…Homo sapiens moved from Africa into the Middle East about 120 Ka, according to fossils at Skhul and Qafzeh caves in Israel [193]. The aba-miRNA-9497 in belladonna with highly homologous to homo sapiens miRNA 378 can target and downregulate human brain-enriched transcription factor (ZNF-691) and gene expression in the human central nervous system [194]. For homo sapiens, foragers have greater complexity than farmers or pastoralists; meanwhile, the Old World foragers had significantly higher anisotropy values than New World foragers, but similarity between hard food foragers and hard food farmers [195].…”

Section: Formation Mechanism Of Depending Functionalmentioning

confidence: 99%

Molecular Mechanism of Functional Ingredients in Barley to Combat Human Chronic Diseases

Zeng

et al. 2020

Oxidative Medicine and Cellular Longevity

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Barley plays an important role in health and civilization of human migration from Africa to Asia, later to Eurasia. We demonstrated the systematic mechanism of functional ingredients in barley to combat chronic diseases, based on PubMed, CNKI, and ISI Web of Science databases from 2004 to 2020. Barley and its extracts are rich in 30 ingredients to combat more than 20 chronic diseases, which include the 14 similar and 9 different chronic diseases between grains and grass, due to the major molecular mechanism of six functional ingredients of barley grass (GABA, flavonoids, SOD, K-Ca, vitamins, and tryptophan) and grains (β-glucans, polyphenols, arabinoxylan, phytosterols, tocols, and resistant starch). The antioxidant activity of barley grass and grain has the same and different functional components. These results support findings that barley grain and its grass are the best functional food, promoting ancient Babylonian and Egyptian civilizations, and further show the depending functional ingredients for diet from Pliocene hominids in Africa and Neanderthals in Europe to modern humans in the world. This review paper not only reveals the formation and action mechanism of barley diet overcoming human chronic diseases, but also provides scientific basis for the development of health products and drugs for the prevention and treatment of human chronic diseases.

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Atropa belladonna Expresses a microRNA (aba-miRNA-9497) Highly Homologous to Homo sapiens miRNA-378 (hsa-miRNA-378); both miRNAs target the 3′-Untranslated Region (3′-UTR) of the mRNA Encoding the Neurologically Relevant, Zinc-Finger Transcription Factor ZNF-691

Cited by 23 publications

References 53 publications

Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: A cross kingdom computational approach

Identification of potential target genes in Homo sapiens, by miRNA of Triticum aestivum: A cross kingdom computational approach

A Timely Review of Cross-Kingdom Regulation of Plant-Derived MicroRNAs

Molecular Mechanism of Functional Ingredients in Barley to Combat Human Chronic Diseases

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