Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population

Almodova, Emiliano D.; Oliveira, Walmar Kerche de; Machado, Lucas Faria Abrahão; Grejo, Juliana Rigotto; Cunha, T.R.; Colaiacovo, Wagner; Ortolan, Érika Veruska Paiva

doi:10.3748/wjg.v19.i13.2060

Cited by 13 publications

(10 citation statements)

References 14 publications

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“…The two main histological types of esophageal cancer are adenocarcinoma and squamous cell carcinoma, which differ according to their risk factors and demographic distributions (Ma et al 2012). Although adenocarcinoma was the most common subtype in white men in the United States since the early 90 s, squamous cell carcinoma is still the most prevalent subtype in the world (Almodova et al 2013;Ren et al 2013). Esophageal squamous cell carcinoma carries a very poor prognosis because many cases go undetected until the disease is at an advanced stage .…”

Section: Introductionmentioning

confidence: 99%

Effect of LPS on the Viability and Proliferation of Human Oral and Esophageal Cancer Cell Lines

Gonçalves

Cappellari

Santos

et al. 2016

Braz. arch. biol. technol.

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The esophagus and mouth tumors are very frequent malignancies worldwide. Lipopolysaccharides (LPS) are capable of regulating gene expression of pro-inflammatory cytokines by binding to toll-like receptor 4 (TLR4). Recent studies show that LPS can increase the migration ability of human esophageal cancer cell line HKESC-2 by increasing its adhesion properties. However, the effect of LPS has not been tested on viability of human esophageal and oral cancer cells. This study aimed to determine the action of LPS on the cell proliferation and viability in

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Section: Introductionmentioning

confidence: 99%

Effect of LPS on the Viability and Proliferation of Human Oral and Esophageal Cancer Cell Lines

Gonçalves

Cappellari

Santos

et al. 2016

Braz. arch. biol. technol.

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“…Most epidemiologic studies have confirmed that alcoholic beverages are a risk factor for ESCC in economically developing and developed areas, although their carcinogenic effects vary with degree of consumption. Alcohol consumption increased the risk of ESCC by 1.6- to 5.3-fold in Asian countries including China 40–47 , Iran 23 , Japan 40 , and India 48, 49 , and about 3-fold in Africa 50–53 and South America 54–57 . In many areas with low incidence rates of ESCC, however, the relationship between alcohol and ESCC is notably stronger, with about 6-fold increase in risk in Europe 58–64 and 9-fold in North America among consumers of alcohol 10, 65–67 .…”

Section: Known and Suspected Risk Factorsmentioning

confidence: 99%

Epidemiology of Esophageal Squamous Cell Carcinoma

2018

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Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of the 456,000 incident esophageal cancers each year. Regions of high incidence include Eastern to Central Asia, along the Rift Valley in East Africa, and into South Africa. There are many causes of ESCC, which vary among regions. Early studies in France associated smoking cigarettes and heavy alcohol consumption with high rates of ESCC, but these factors cannot explain the high incidence in other regions. We discuss other risk factors for ESCC, including polycyclic aromatic hydrocarbons from a variety of sources, high-temperature foods, diet, and oral health and the microbiome-all require further research. A growing list of defined genomic regions affects susceptibility, but large genome-wide association studies have been conducted with ethnic Chinese subjects only; more studies are called for in the rest of Asia and Africa. ESCC has been understudied, but growing infrastructure in more high-incidence countries will allow rapid progress in our understanding.

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“…In addition to different molecules contributing to ESCC tumorigenesis in Indian and Chinese population, there is life style mainly diet pattern (Chinese and Indian particularly South Indians either prefers to have spicy food and/or consumption of pickled vegetables, and intake of alcohol and tobacco). In addition to these, to establish what are common factors among Chinese and India population, a comparative analysis is required to establish common pre-disposing and risk factors (achalasia, atrophic gastritis 83 , an infection by cytotoxin-associated gene A (CagA)-positive Helicobacter pylori 84 , injury to the esophagus, consumption of pickled vegetables, Plummer Vinson syndrome, Chaggas-associated mega-esophagus, and a history of certain head and neck cancers) 85 .…”

Section: Resultsmentioning

confidence: 99%

ESCC ATLAS: A population wide compendium of biomarkers for Esophageal Squamous Cell Carcinoma

Tungekar¹,

Mandarthi

Mandaviya

et al. 2018

Sci Rep

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Esophageal cancer (EC) is the eighth most aggressive malignancy and its treatment remains a challenge due to the lack of biomarkers that can facilitate early detection. EC is identified in two major histological forms namely - Adenocarcinoma (EAC) and Squamous cell carcinoma (ESCC), each showing differences in the incidence among populations that are geographically separated. Hence the detection of potential drug target and biomarkers demands a population-centric understanding of the molecular and cellular mechanisms of EC. To provide an adequate impetus to the biomarker discovery for ESCC, which is the most prevalent esophageal cancer worldwide, here we have developed ESCC ATLAS, a manually curated database that integrates genetic, epigenetic, transcriptomic, and proteomic ESCC-related genes from the published literature. It consists of 3475 genes associated to molecular signatures such as, altered transcription (2600), altered translation (560), contain copy number variation/structural variations (233), SNPs (102), altered DNA methylation (82), Histone modifications (16) and miRNA based regulation (261). We provide a user-friendly web interface (http://www.esccatlas.org, freely accessible for academic, non-profit users) that facilitates the exploration and the analysis of genes among different populations. We anticipate it to be a valuable resource for the population specific investigation and biomarker discovery for ESCC.

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Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population

Abstract: There was an association by univariate conditional logistic regression between AG and ECSS in this sample of Latin-American population.

Cited by 13 publications

References 14 publications

Effect of LPS on the Viability and Proliferation of Human Oral and Esophageal Cancer Cell Lines

Effect of LPS on the Viability and Proliferation of Human Oral and Esophageal Cancer Cell Lines

Epidemiology of Esophageal Squamous Cell Carcinoma

ESCC ATLAS: A population wide compendium of biomarkers for Esophageal Squamous Cell Carcinoma

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