Atrophie iléale primitive associée à une colite collagène : efficacité clinique de la corticothérapie

Herber, A; Larvol, L; Brisset, Florence; Bruch, Jean Frédéric; Cervoni, Jean–Paul; Levecq, H

doi:10.1016/s0399-8320(04)95163-9

Cited by 3 publications

(1 citation statement)

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“…In addition, we excluded other concurrent diseases associated with segmental mucosal atrophy, such as ischemic colitis. Although not in the colon, advanced mucosal atrophy has been observed in the duodenum and ileum of patients with CC and celiac disease [12]. However, our patient's duodenal and ileal biopsies did not display any signs of mucosal atrophy.…”

Section: Discussioncontrasting

confidence: 59%

Mucosal atrophy in collagenous colitis: a case report

Majores

Wunsch²,

Blume³

et al. 2011

BMC Gastroenterol

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BackgroundMucosal atrophy as a potential cause of impaired colonic compliance has not yet been described as a complication in Collagenous Colitis (CC).Case presentationWe present a 51-year-old female patient with a 20-year history of diarrhea and diagnosed with CC ten years prior to her presentation. We reviewed reports from three colonoscopies performed after the diagnosis. Overall 12 biopsies obtained in the last two colonoscopies were re-analyzed by two pathologists blinded to the aim of the study. Besides the typical histological findings of CC, the endoscopic appearance was normal, and no histological signs of atrophy were found during the first colonoscopy. Surprisingly, the second and third colonoscopy revealed a region of advanced segmental mucosal atrophy in the cecum with the mucosal height normalizing toward the transverse colon. This pattern of atrophy was inversely related to the pattern of sub-epithelial collagen deposition, which increased toward the rectum.ConclusionIf no chance occurrence, our observation supports the idea that additional factors, probably luminal in nature, may be co-responsible for the mucosal atrophy in this case. Thus, mucosal atrophy in the proximal colon appears to be a new candidate among the growing list of rare complications associated with long standing CC.

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Section: Discussioncontrasting

confidence: 59%