Atrophy of the Lymphoid Tissues of Mice Induced by Extracts of the Submaxillary Gland

Takeda, Takeshi; Yamasaki, Yoshihiro; Yamabe, Hirohiko; Suzuki, Y.; Haebara, Hideyuki; Irino, T; Grollman, Arthur P.

doi:10.3181/00379727-126-32404

Cited by 13 publications

(2 citation statements)

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“…The possibility that this control mechanism is abrogated by drying up of the secretory apparatus, as the tumor progresses, as evidenced by squamous metaplasia of duct systems and ablation of acini by ductal tumor cells, seems a logical offshoot. This hypothesis is further supported by the observations of Martinez-Hernandez et al (1973) and Takeda et al (1967) who showed that the submaxillary gland of rodents may be intimately involved in tbe development of thymic lymphocytes and that ablation or infarction of the submaxillary gland produces lymphopenia.…”

Section: Discussionsupporting

confidence: 55%

Leukocyte mediated cytotoxicity of chemically induced rat salivary gland neoplasms

Brown

Frankel

1974

J Oral Pathology Medicine

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Chemically induced tumors of the rat submaxillary glands were tested for the presence of tumor antigens by in vitro leukocyte mediated cytotoxicily assays. Since it has been reported that the saliva of humans wilh oral cancer contains markedly elevated levels of secretory antibody, the rats' saliva specimens were also tested for blocking and/or potentiating "antibody" activity.The results indicate that saliva from lumor-bearing animals potentiated tumor cell killing if either the tumor cells or leukocytes were pretreated. The effect was much more marked when tumor cells were pretreated. Furthermore, the addition of saliva to tumor cells imparted an immunologic cross reactivity which was not present with untreated tumor cells. Control saliva occasionally produced a similar effect, but not as consistently or with the potency of saliva from tumor-bearing animals. Heat inactivation did not abrogate this potentiation.It is inferred that this may indicate a new system of immunologic surveillance, i.e. arming or potentiation of leukocytes by soluble tumor antigens in glandular secretions.

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Section: Discussionsupporting

confidence: 55%

Leukocyte mediated cytotoxicity of chemically induced rat salivary gland neoplasms

Brown

Frankel

1974

J Oral Pathology Medicine

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“…These may be either naturally occurring antigens or determinants artificially coupled t o the red cell surface [2]. By the use of appropriate anti-Ig "developing sera", cells secreting Ig of other classes can also be detected [3]. These assays, however, do not detect all Ig-secreting cells, but only that fraction which secretes antibodies specific for target cell determinants.…”

Section: Introductionmentioning

confidence: 99%

Immunosuppressive activity of submaxillary gland extracts of the mouse 1. Effect on antibody formation in response to sheep red blood cells

Koch

Rowe

1976

Eur J Immunol

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Aqueous extracts of mouse submaxillary glands yield six peaks on Sephadex G-75 columns, each containing several molecular species. Two of these fractions (III and IV) have a profound effect on the immune response. When given a day before immunization with sheep erythrocytes, the number of antibody-producing cells is reduced ten-fold or more, and the switch from IgM to IgG is virtually absent. Administration two days before or on the day of immunization results in about 50% depression; outside this range there is no effect. The dose-response curve is of sigmoid shape, with the median at about 0.5 mg of fraction III/40 g mouse, reaching an asymptote after doses of greater than or equal to 5 mg at about 5% of the response of untreated mice. Depression of the primary response does not prevent the development of immunological memory: the secondary response is typical in the early and predominant appearance of IgG-producing cells, although their numbers are somewhat lower than in the controls which received no treatment before primary immunization. Treatment on the day before boosting abrogates the secondary response. The immunotranquilizer from mouse submaxillary glands acts equally well on syngeneic and allogeneic recipients, affecting the earliest stage of the immune response. The results are compatible with the induction of a temporary block in the development of helper T cells.

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Parenterally administered salivary tissue extracts reduce outputs of Na+ and K+ associated with bile salt-induced damage of rat oxyntic mucosa

Tepperman

Soper

1984

Digest Dis Sci

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Extirpation of the major salivary glands in rats has been shown to exacerbate the ionic fluxes associated with pharmacologically-induced damage to the gastric mucosal barrier. In the present study we have investigated the effect of the administration of a crude extract of submandibular-sublingual salivary glands on gastric secretion and gastric mucosal barrier integrity in the rat. The extract was administered in a dose (4 mg protein) which would reduce established acid secretion by 30%. Chronic parenteral (intraperitoneal) administration of salivary gland extract but not phosphate buffer resulted in a reduction in the luminal appearance of Na+ and K+ associated with bile salt-induced damage (5 mM sodium taurocholate in 150 mM HCl) to the gastric mucosa of sialoadenectomized animals. Oral administration of the extract depressed its protective action. Boiling the extract prior to parenteral administration also abolished its ability to protect the mucosa. Acute administration of the extract by intraperitoneal injection only 30 min prior to bile salt treatment was also ineffective. These results suggest that chronic parenteral but not enteral treatment with a crude salivary gland extract aids in the maintenance of the gastric mucosal barrier in sialoadenectomized rats. The inability of acute administration of the extract to reduce the net fluxes of Na+ and K+ suggests that its mode of action is not entirely dependent upon an inhibition of gastric acid secretion.

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Atrophy of the Lymphoid Tissues of Mice Induced by Extracts of the Submaxillary Gland

Cited by 13 publications

References 0 publications

Leukocyte mediated cytotoxicity of chemically induced rat salivary gland neoplasms

Leukocyte mediated cytotoxicity of chemically induced rat salivary gland neoplasms

Immunosuppressive activity of submaxillary gland extracts of the mouse 1. Effect on antibody formation in response to sheep red blood cells

Parenterally administered salivary tissue extracts reduce outputs of Na+ and K+ associated with bile salt-induced damage of rat oxyntic mucosa

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