Atropine and Other Anticholinergic Drugs

Le VR, version russe du neurotoxique organophosphoré VX

“…Administrée suffisamment tôt, elle participe à l'action antiépileptique du traitement habituel aux NOP [47]. Un effet synergique est obtenu lors de l'administration simultanée d'une oxime [48], effet d'autant plus important que l'oxime associée est efficace. Un autre alcaloïde, la scopolamine, fait l'objet de recherche en vue de remplacer l'atropine dans l'autoinjecteur utilisable en urgence par le personnel militaire américain.…”

Prophylactic and Therapeutic Measures in Nerve Agents Poisoning

“…Such drugs are classified as muscarinic receptor antagonists, and they are not able to counteract the nicotinic signs of intoxication like muscle fasciculation, muscle fatigue, and weakness (McDonough and Shih, 2007). Anticholinergics have optimal efficacy during the cholinergic phase (i.e., from exposure to approximately 5 min after onset of seizures).…”

Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates

“…In view of this difficulty, it is mandatory to know whether the standard treatment of poisoning by organophosphorus pesticides and nerve agents, i.e. atropine and an oxime [5,6], is at least without harm in carbamate poisoning. In fact, there is an ongoing debate whether oximes should be administered to carbamate poisoned patients and a number of authors do not recommend oximes in carbamate poisoning [6][7][8].…”