Atropine-Phosphotungestate Polymeric-Based Metal Oxide Nanoparticles for Potentiometric Detection in Pharmaceutical Dosage Forms

Abstract

The new research presents highly conductive polymeric membranes with a large surface area to volume ratio of metal oxide nanoparticles that were used to determine atropine sulfate (AT) in commercial dosage forms. In sensing and biosensing applications, the nanomaterials zinc oxide (ZnONPs) and magnesium oxide (MgONPs) were employed as boosting potential electroactive materials. The electroactive atropine phosphotungstate (AT-PT) was created by combining atropine sulfate and phosphotungstic acid (PTA) and mixing it with polymeric polyvinyl chloride (PVC) with the plasticizer o-nitrophenyl octyl ether (o-NPOE). The modified sensors AT-PT-ZnONPs or AT-PT-MgONPs showed excellent selectivity and sensitivity for the measurements of atropine with a linear concentration range of 6.0 × 10−8 − 1.0 × 10−3 and 8.0 × 10−8 − 1.0 × 10−3 mol L−1 with regression equations of E(mV) = (56 ± 0.5) log [AT] − 294 and E(mV) = (54 ± 0.5) log [AT] − 422 for AT-PT-NPs or AT-PT-MgONPs sensors, respectively. The AT-PT coated wire sensor, on the other hand, showed a Nernstian response at 4.0 × 10−6 − 1.0 × 10−3 mol L−1 and a regression equation E(mV) = (52.1 ± 0.2) log [AT] + 198. The methodology-recommended guidelines were used to validate the suggested modified potentiometric systems against various criteria.

Highly Precise and Sensitive Approach for Direct Electrochemical Sensing of Phosphates Using Zinc Ferrite Impregnated-Polyaniline Coated Electrodes

“…Among the different CPs, Polyaniline (PANI) is more promising due to its low cost monomer, easy and variety of synthetic methods, existence in different oxidation states, simple doping de-doping chemistry and good electrical conductivity [20]. The combination of metal oxide particles with PANI can lead to a range of phenomenon, including electrical interactions, charge transfer processes, and morphological changes, which are quite helpful for the enhancement of sensing properties [21].…”

Exploiting of Green Synthesized Metal Oxide Nanoparticles in the Potentiometric Determination of Metformin Hydrochloride in Pharmaceutical Products

“…Hundreds of different sensors have been developed in this field and published in the literature to date [ 24 ]. Today, potentiometric sensors are the focus of interest due to the successful development of sensors in many applications [ 25 – 27 ]. Due to the high demand and constant technological progress, the world of sensors is diverse and rapidly evolving.…”

Electrochemical Determination of Anti‐Cancer Drug Dabrafenib with High Sensitivity Using Multi‐Walled Carbon Nano Tubes Modified Glassy Carbon Electrode

“…[7] In the literature survey, numerous analytical methods have been developed for the quantitative analysis of Dabrafenib (DAB), including high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS), fluorescence technique, and electrophoresis. [8][9][10][11][12][13][14][15][16][17][18][19][20] While these methods are effective and sensitive in detecting and quantifying DAB, they are often associated with drawbacks such as high costs and environmental concerns arising from the extensive use of organic solvents. Additionally, these methods may require lengthy analysis times and the expertise of trained professionals to operate analytical instruments effectively.…”