2024
DOI: 10.1002/anie.202403401
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Atropisomeric Carboxylic Acids Synthesis via Nickel‐Catalyzed Enantioconvergent Carboxylation of Aza‐Biaryl Triflates with CO2

Xiao‐Wang Chen,
Chao Li,
Yong‐Yuan Gui
et al.

Abstract: Upgrading CO2 to value‐added chiral molecules via catalytic asymmetric C−C bond formation is a highly important yet challenging task. Although great progress on the formation of centrally chiral carboxylic acids has been achieved, catalytic construction of axially chiral carboxylic acids with CO2 has never been reported to date. Herein, we report the first catalytic asymmetric synthesis of axially chiral carboxylic acids with CO2, which is enabled by nickel‐catalyzed dynamic kinetic asymmetric reductive carbox… Show more

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Cited by 10 publications
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