ATSDR evaluation of the health effects of zinc and relevance to public health

Roney, Nickolette; Osier, Mark R; Paikoff, Sari J.; Smith, Cassandra V.; Williams, Malcolm; Rosa, Christopher T. De

doi:10.1177/0748233706074173

Cited by 31 publications

(15 citation statements)

References 245 publications

(453 reference statements)

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“…This element has many regulations on the function of many metalloenzymes. Depressed mental function is one of the problems caused by zinc deficiency [3]. In addition, it was observed that zinc supplementation has been proven to decrease diarrhea morbidity and mortality [4].…”

mentioning

confidence: 99%

Determination of Zinc, Copper, Iron, and Manganese in Different Regions of Lamb Brain

Bakırdere

Kizilkan

Yaman

2010

Biol Trace Elem Res

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The levels of zinc, copper, iron, and manganese were measured in the hippocampus, thalamus, gyrus cinguli, hypothalamus, and in the prefrontal, parietal, temporal, and occipital cortexes of lamb brain by flame atomic absorption spectrometry. Standard addition method was also applied to samples and it was observed that there was no matrix interference affecting the determination of elements interested. In the determination of Cu, a slotted tube atom trap was used to improve sensitivity. One-way analysis of variance was used for the statistical evaluation of the results for each element. Limit of detection results for Zn, Cu, Fe, and Mn were found to be 24, 4.5, 60, and 25 ng/mL, respectively. Region-specific differences were found for all elements interested. Mn concentration ranging from 0.29 ± 0.04 to 0.61 ± 0.04 mg/kg was found to be the lowest in all brain regions among the all elements interested.

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confidence: 99%

Determination of Zinc, Copper, Iron, and Manganese in Different Regions of Lamb Brain

Bakırdere

Kizilkan

Yaman

2010

Biol Trace Elem Res

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“…V is found in different oxidation states, the most common being vanadium pentoxide is known to induce aneugenic events (Zhong et al 1994). Concerning Zn exposure, even if at low concentrations, this PHE acts as a protector of genome stability, at concentrations higher than physiological ones, weak clastogenic effects were reported (Roney et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Potentially harmful elements in house dust from Estarreja, Portugal: characterization and genotoxicity of the bioaccessible fraction

Plumejeaud

Reis

Tassistro

et al. 2016

Environ Geochem Health

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Due to their behavioral characteristics, young children are vulnerable to the ingestion of indoor dust, often contaminated with chemicals that are potentially harmful. Exposure to potentially harmful elements (PHEs) is currently exacerbated by their widespread use in several industrial, agricultural, domestic and technological applications. PHEs cause adverse health effects on immune and nervous systems and can lead to cancer development via genotoxic mechanisms. The present study is an integrated approach that aims at assessing the genotoxicity of bioaccessible PHEs following ingestion of contaminated house dust. A multidisciplinary methodology associating chemical characterization of five house dust samples, extraction of the bioaccessible PHEs in gastric extracts by the unified BARGE method, determination of the bioaccessible fraction and in vitro genotoxicity of gastric extracts in adenocarcinoma gastric human (AGS) cells was developed. The five gastric extracts induced dose-dependent genotoxicity in AGS cells. Copper (bioaccessible concentration up to 111 mg/kg) was probably the prevalent PHE inducing primary DNA damage (up to 5.1-fold increase in tail DNA at 0.53 g/l of gastric extract). Lead (bioaccessible concentration up to 245 mg/kg) was the most prevalent PHE inducing chromosome-damaging effects (r = 0.55; p < 0.001 for micronucleated cells induction). The association of principal component analysis and Spearman's correlations was decisive to understand the chromosome-damaging properties of the bioaccessible PHEs in AGS cells. This methodology could be used on a larger-scale study to provide useful information for science-based decision-making in regulatory policies, and a better estimation of human exposure and associated health risks.

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“…Compensation and Liability Act (CERCLA). [46], ATSDR and US Department of Human Health Service, published on the toxicological profiles of zinc metabolism including absorption, distribution, metabolism and excretion (ADME).…”

Section: Discussionmentioning

confidence: 99%

Metabolism and Toxicity of High Doses of Cyclo (his-pro) Plus Zinc in Healthy Human Subjects

Uyemura¹,

Dhanani²,

Yamaguchi³

et al. 2010

J Drug Metabol Toxicol

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In our previous studies, Cyclo-Z (Cyclo [His-Pro], [CHP] plus zinc) treatment in animals improved insulin sensitivity. However, the adverse effects of these ingredients in humans have not yet been established. his study was to evaluate the pharmacokinetics and possible toxicity of CHP and zinc in healthy human subjects. Forty-nine healthy subjects were randomly divided into 4 groups of 11-15 subjects. ll the subjects consumed 8 study capsules and then submit to a battery of blood draws. Group 1 consisted of subjects who received 8 placebo control capsules. Individuals in Group 2 received 2 capsules of Cyclo-Z containing 3 mg CHP plus 20 mg zinc, in addition to 6 capsules of placebo. Group 3 subjects received 4 capsules of Cyclo-Z and 4 capsules of placebo. Finally, Group 4 individuals received 8 capsules of Cyclo-Z. Blood samples were collected at 0, 2, 4, 8, and 24 hours for the analysis of liver, kidney and lipid panels. Biochemical analyses were also conducted to measure CHP, zinc, and cooper levels for pharmacokinetic analyses. No side effects were experienced in any of the subjects based on physical and blood chemistry examinations. Plasma CHP levels increased at 4 hours in each subject treated with CHP. However, all plasma CHP levels returned to normal levels by 24 hours. Plasma zinc levels were stable and did not increase beyond normal levels. However, a slight increase of plasma zinc at 4 hours was found for Group 4 who received160 mg zinc. There was no copper deficiency found in any of the test subjects. This clinical study demonstrated that acute intake of 24 mg CHP plus 160 mg zinc did not show any clinical side effects or copper deficiency in healthy subjects. .

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ATSDR evaluation of the health effects of zinc and relevance to public health

Cited by 31 publications

References 245 publications

Determination of Zinc, Copper, Iron, and Manganese in Different Regions of Lamb Brain

Determination of Zinc, Copper, Iron, and Manganese in Different Regions of Lamb Brain

Potentially harmful elements in house dust from Estarreja, Portugal: characterization and genotoxicity of the bioaccessible fraction

Metabolism and Toxicity of High Doses of Cyclo (his-pro) Plus Zinc in Healthy Human Subjects

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