Attachment Formation After Transplantation of Teeth Cultured With Enamel Matrix Derivative in Dogs

Saito, Akira; Saito, Emiko; Yoshimura, Yoshitaka; Takahashi, Katsuroku; Handa, Ryohei; Honma, Yoshiyuki; Ohata, Noboru

doi:10.1902/jop.2011.100596

Cited by 9 publications

(15 citation statements)

References 22 publications

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“…One study was a randomized controlled trial,29 but the other studies were controlled trials 17,24,25,26,32. The method of randomization, allocation concealment and masking of examiners for outcome assessment was unclear in this randomized controlled trial, and masking of examiners for outcome assessment was also unclear in the controlled trials.…”

Section: Resultsmentioning

confidence: 99%

“…Endodontic treatment: Teeth were endodontically treated and filled with calcium hydroxide or gutta percha root canal filling material prior to replantation in all studies except one study 17,19,24-26,32…”

Section: Resultsmentioning

confidence: 99%

“…Use of EDTA prior to EMD application: Four studies used EDTA prior to EMD,24,25,29,32 and two studies did not use EDTA 17,26…”

Section: Resultsmentioning

confidence: 99%

“…Five studies were selected for analysis as described in Table 3 24-26,29,32. Quantitative comparison of the studies could not be performed because there were missing data in our outcome categories, and no standard errors presented 25,26,29,32.…”

Section: Resultsmentioning

confidence: 99%

“…Quantitative comparison of the studies could not be performed because there were missing data in our outcome categories, and no standard errors presented 25,26,29,32. Therefore, qualitative analysis was performed to assess the effect of EMD on periodontal healing and resorption in replanted teeth.…”

Section: Resultsmentioning

confidence: 99%

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Enamel matrix derivative for replanted teeth in animal models: a systematic review and meta-analysis

Kim

Ryu

2013

Restor Dent Endod

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ObjectivesTo investigate the effect of enamel matrix derivative (EMD) on periodontal healing of replanted teeth in animal models.Materials and MethodsThe authors searched MEDLINE, PubMed, EMBASE, Cochrane Library, Web of Knowledge and Scopus for articles published up to Oct 2012. Animal studies in which EMD was applied in transplanted or replanted teeth with adequate controls and histological data were considered. Normal periodontal healing or root resorption determined by histology after EMD was applied in replanted teeth with adequate controls was used as outcome measures. The following search strategy was used: ('Emdogain' OR 'enamel matrix proteins' OR 'enamel matrix derivative') AND ('avulsion' OR 'transplantion' OR 'autotransplantation' OR 'replantation').ResultsSix animal studies were included in the final review. There was great heterogeneity in study design among included studies. Two studies with similar study designs were identified and analyzed by a meta-analysis. The pooled estimates showed a significantly higher normal healing and surface resorption and significantly less inflammatory and replacement resorption in EMD-treated groups compared with non-EMD-treated groups.ConclusionsWith the limitations of this systematic review, the use of EMD led to greater normal periodontal healing and surface root resorption and less inflammatory and replacement root resorption in the presence of periodontal ligaments. However, no definite conclusion could be drawn with regard to the effect of EMD on periodontal healing and root resorption when no periodontal ligaments exist.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Use of EDTA prior to EMD application: Four studies used EDTA prior to EMD,24,25,29,32 and two studies did not use EDTA 17,26…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Enamel matrix derivative for replanted teeth in animal models: a systematic review and meta-analysis

Kim

Ryu

2013

Restor Dent Endod

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Periodontal Tissue Engineering Strategies Based on Nonoral Stem Cells

Requicha

Viegas

Muñoz

et al. 2013

The Anatomical Record

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Periodontal disease is an inflammatory disease which constitutes an important health problem in humans due to its enormous prevalence and life threatening implications on systemic health. Routine standard periodontal treatments include gingival flaps, root planning, application of growth/differentiation factors or filler materials and guided tissue regeneration. However, these treatments have come short on achieving regeneration ad integrum of the periodontium, mainly due to the presence of tissues from different embryonic origins and their complex interactions along the regenerative process. Tissue engineering (TE) aims to regenerate damaged tissue by providing the repair site with a suitable scaffold seeded with sufficient undifferentiated cells and, thus, constitutes a valuable alternative to current therapies for the treatment of periodontal defects. Stem cells from oral and dental origin are known to have potential to regenerate these tissues. Nevertheless, harvesting cells from these sites implies a significant local tissue morbidity and low cell yield, as compared to other anatomical sources of adult multipotent stem cells. This manuscript reviews studies describing the use of non‐oral stem cells in tissue engineering strategies, highlighting the importance and potential of these alternative stem cells sources in the development of advanced therapies for periodontal regeneration. Anat Rec, 297:6–15. 2014. © 2013 Wiley Periodicals, Inc.

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Effect of EMD on the orthodontically induced root resorption repair process in rats

Zhou

et al. 2018

J Orofac Orthop

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Attachment Formation After Transplantation of Teeth Cultured With Enamel Matrix Derivative in Dogs

Abstract: Transplantation of tissue-cultured teeth decreased epithelial downgrowth and increased connective tissue attachment on the root-planed surface. Furthermore, EMD could remarkably increase the new connective tissue attachment in this periodontal regenerative technique.

Cited by 9 publications

References 22 publications

Enamel matrix derivative for replanted teeth in animal models: a systematic review and meta-analysis

Enamel matrix derivative for replanted teeth in animal models: a systematic review and meta-analysis

Periodontal Tissue Engineering Strategies Based on Nonoral Stem Cells

Effect of EMD on the orthodontically induced root resorption repair process in rats

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