Actuarial senescence almost certainly occurs in all birds and mammals. It is by no means certain that it occurs in all poikilotherms, beyond the accumulation of evident injury with age. The ageing of birds and mammals has been termed "endogenous", and it has been suggested that this type of ageing is in some way connected either with the evolution of homoiothermy or of a fixed adult size. Bidder (1925, 1932) attributed it to the direct action of a growth-inhibitory mechanism evolved during the transition to life on land. From maximum age records it is evident that the lifespan of smaller vertebrates declines fairly steadily from phylum to phylum in ascending phylogenetic order. It is longest in fish, amphibia and reptiles. We have records of 35 years in Triton (Smith, 1951) and 40 years in goldfish (Harvey and Hems, 1948). The lifespan of birds is in many cases substantially greater than that of mammals of comparable size and activity. The lifespan of the laboratory mouse is normally less than three years, while that of a chaffinch in captivity may exceed 20 (29-Moltoni, 1947). This suggests that in phylogeny other causes than the increase in metabolic rates have operated to shorten the maximum lifespan-the metabolism of small birds measured by their oxygen consumption is higher than that of rodents, and apparently it does not decline with age like that of many mammals (Benedict and Talbot, 1921). The growth of birds, as Bacon (1645) pointed out, ceases relatively earlier than that of mammals, and much more definitively; the epiphyses of rats never join, and they may continue in growth, or be made to grow in response to somatotrophin, at any age, while no further growth occurs in birds after the attainment of adult size. There are also important discrepancies between the maximum ages reported in closely related mammals. The most extensive figures are for rodents: thus Mus bactrianus has been reported to live and remain fertile longer than any strain of Mus musculus (Green, 1932), while species of Peromyscus and Perognathus live almost twice as long [Peromyscus maniculatus gambelli 5 years 8 months (Sumner, 1922);