Attainment of Goal and Normalized Lipid Levels With Lipid-Modifying Therapy in Malaysia

Hsu, Tun-Ying; Chirovsky, Diana; Moy, Foong Ming; Ambegaonkar, Baishali

doi:10.1016/j.clinthera.2013.02.004

Cited by 1 publication

(4 citation statements)

References 49 publications

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“…In this study, in fact the attainment of HDL-C normal levels was very minimal with only 2% more patients achieving goal at follow up among high-risk patients. Indeed our pooled analysis is in line with other previous findings from individual country data (20)(21)(22) which reported similar findings with both LDL-C and HDL-C target/normal level attainment. Observations demonstrate a need for more effective therapy to enhance multiple goal attainment among high-risk patients.…”

Section: Discussionsupporting

confidence: 93%

“…Data for ambulatory patients at least 35 years of age initiated on LMT between January 2001 and June 2007 in Thailand were identified from medical records extracted from five main teaching hospitals. In Hong Kong , Korea and Malaysia , the index period spanned from January 2004 to December 2006. Complete outpatient data were extracted randomly from patient medical records and conducted at five government hospitals (includes two teaching hospitals) in Hong Kong, 16 hospitals in Korea and 9 primary care practices within Malaysia.…”

Section: Methodsmentioning

confidence: 99%

“…Data for ambulatory patients at least 35 years of age initiated on LMT between January 2001 and June 2007 in Thailand (20) were identified from medical records extracted from five main teaching hospitals. In Hong Kong (21), Korea and Malaysia (22), the All eligible patients were required to have complete lipid panel data, including TC, LDL-C, HDL-C and TG, within 12-24 months before and after the index date and have been continuously treated with a LMT from the index date to at least 6 weeks prior to the follow-up date. Treatment gaps of up to 6 weeks were allowed after LMT initiation except for the first 6 weeks following the index date.…”

Section: Methodsmentioning

confidence: 99%

“…This longitudinal study presents a pooled analysis of attainment of goal/normal lipid levels in regular clinical practice from a series of five retrospective observational studies conducted in Malaysia, Korea, Hong Kong, Thailand and Philippines as part of the Pr evalence and Treatment Patterns i n Patients with M ixed Dyslipidaemia U sing L ipid‐Lowering A gents (PRIMULA) study. Individual country data from Thailand , Hong Kong and Malaysia have since been published.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence of lipid abnormalities and attainment of normal lipid levels among patients with dyslipidaemia: a pooled analysis of observational studies from five Asian countries

Unniachan¹,

Bash

Khovidhunkit

et al. 2014

Int J Clin Pract

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Aims: Guidelines emphasise the importance of low-density lipoprotein cholesterol (LDL-C) goals for cardiovascular risk reduction. Given the importance of association between high-density lipoprotein (HDL-C) and triglycerides (TG) normal levels and cardiovascular risk, there is an additional need to further evaluate diverse dyslipidaemic populations. Methods: A retrospective longitudinal observational study of patients aged ≥ 35 years on lipid-modifying therapy (LMT) for ≥ 12 months was conducted from patient records pooled from five Asian countries (Malaysia, Korea, Hong Kong, Thailand and Philippines). The prevalence of lipid abnormalities and goal attainment was assessed 12 months before and after LMT initiation. Results: Among 3256 patients (mean age -58.6 years, 50.4% men), 65.4% were highrisk patients and 88% were on statin therapy. At baseline 94.7% of all patients had at least one abnormal lipid value elevated, LDL-C (86.2%) being the most pre- were less likely to reach LDL-C goals. Fewer characteristics were independently associated with reaching normal levels of HDL-C and TG and attaining at least two normal lipid levels. Conclusions: While current LMT reduced the prevalence of dyslipidaemia, a third of patients still failed to achieve target/normal levels. We highlight country differences and the importance of improving therapy to attain multiple lipid goals/normal levels. What's knownPrevious studies have shown that despite optimal lipid-lowering therapy lipid goal/normal level attainment is low, more so in high-risk individuals. Studies quantifying lipid levels among those in the Asia Pacific region overall, and by patient and country subgroups are limited. What's newIn this large cross-sectional study fielded in five Asian countries, we highlight the country differences and patient characteristics by lipid level. Observations suggest that despite current treatment, dyslipidaemia is a still widespread unmet medical for which effective management strategies are still needed.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%